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Bemer PEMF Reduces Cancer Cell Radioresistance


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Publication Title | Bemer PEMF Reduces Cancer Cell Radioresistance

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Citation: Storch K, Dickreuter E, Artati A, Adamski J, Cordes N (2016) BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage. PLoS ONE 11(12): e0167931. doi:10.1371/journal.pone.0167931
Editor: Kerstin Borgmann, Universitatsklinikum Hamburg-Eppendorf, GERMANY
Received: August 1, 2016 Accepted: November 22, 2016 Published: December 13, 2016
Copyright: © 2016 Storch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability Statement: All relevant data are within the paper.
Funding: The research and authors were in part supported by the BEMER Int. AG (Liechtenstein) and grants from the Deutsche Krebshilfe (108976 to N.C.), the European Union (RADIATE; GA No. 642623 to N.C.) and the EFRE Europa ̈ische Fonds fu ̈r regionale Entwicklung, Europa fo ̈rdert Sachsen (100066308). This work was also supported in part by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.). The
RESEARCH ARTICLE
BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage
Katja Storch1,2☯, Ellen Dickreuter1,2☯, Anna Artati3, Jerzy Adamski3,4,5, Nils Cordes1,2,6,7,8*
1 OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universita ̈t Dresden, Dresden, Germany, 2 Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology, Dresden, Germany, 3 Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum Mu ̈ nchen, German Research Center for Environmental Health, Neuherberg, Germany, 4 Lehrstuhl fu ̈r Experimentelle Genetik, Technische Universita ̈t Mu ̈nchen, Freising- Weihenstephan, Germany, 5 German Center for Diabetes Research (DZD e.V.), Mu ̈nchen-Neuherberg, Germany, 6 Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universita ̈t Dresden, Dresden, Germany, 7 German Cancer Consortium (DKTK), Dresden, Germany,
8 German Cancer Research Center (DKFZ), Heidelberg, Germany ☯ These authors contributed equally to this work.
* Nils.Cordes@OncoRay.de
Abstract
Each year more than 450,000 Germans are expected to be diagnosed with cancer subse- quently receiving standard multimodal therapies including surgery, chemotherapy and radiotherapy. On top, molecular-targeted agents are increasingly administered. Owing to intrinsic and acquired resistance to these therapeutic approaches, both the better molecular understanding of tumor biology and the consideration of alternative and complementary therapeutic support are warranted and open up broader and novel possibilities for therapy personalization. Particularly the latter is underpinned by the increasing utilization of non- invasive complementary and alternative medicine by the population. One investigated approach is the application of low-dose electromagnetic fields (EMF) to modulate cellular processes. A particular system is the BEMER therapy as a Physical Vascular Therapy for which a normalization of the microcirculation has been demonstrated by a low-frequency, pulsed EMF pattern. Open remains whether this EMF pattern impacts on cancer cell sur- vival upon treatment with radiotherapy, chemotherapy and the molecular-targeted agent Cetuximab inhibiting the epidermal growth factor receptor. Using more physiological, three- dimensional, matrix-based cell culture models and cancer cell lines originating from lung, head and neck, colorectal and pancreas, we show significant changes in distinct intermedi- ates of the glycolysis and tricarboxylic acid cycle pathways and enhanced cancer cell radio- sensitization associated with increased DNA double strand break numbers and higher levels of reactive oxygen species upon BEMER treatment relative to controls. Intriguingly, exposure of cells to the BEMER EMF pattern failed to result in sensitization to chemother- apy and Cetuximab. Further studies are necessary to better understand the mechanisms
PLOS ONE | DOI:10.1371/journal.pone.0167931 December 13, 2016 1 / 19

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