Page | 001 Brazilian Journal of Physical Therapy 26 (xxxx) 100449
Brazilian Journal of
Physical Therapy
https://www.journals.elsevier.com/brazilian-journal-of-physical-therapy
ORIGINAL RESEARCH
Effects of pulsed electromagnetic field therapy on fatigue, walking performance, depression, and quality of life in adults with multiple sclerosis: a randomized placebo-controlled trial
Anabel Granja-Domíngueza, Anja Hochsprungb, Carlos Luque-Morenoc,d,*, Eleonora Magnic, Shahid Escudero-Uribeb, Beatriz Heredia-Camachoe, Guillermo Izquierdo-Ayusoa, Alberto Marcos Heredia-Rizoc,f
a Fundacion DINAC, Hospital Vithas Nisa, Sevilla, Spain
b Hospital Universitario Virgen Macarena, Andalusian Health Service, Sevilla, Spain
c Physical Therapy Department, Faculty of Nursing, Physical Therapy and Podiatry, University of Sevilla, Sevilla, Spain d Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain
e Centro de Fisioterapia Fisin, Dos Hermanas, Sevilla, Spain
f UMSS Research Group, University of Sevilla, Sevilla, Spain
Received 9 September 2021; received in revised form 8 September 2022; accepted 3 October 2022 Available online 13 October 2022
KEYWORDS
Fatigue;
Magnetic field therapy; Neurologic gait disorders;
Placebo effect; Quality of life; Relapsing-remitting multiple sclerosis
Abstract
Background: Multiple sclerosis has a great disability burden. Management of the disease is com- plex, and patients often seek new conservative approaches.
Objective: To investigate the effect of low-frequency pulsed electromagnetic field (PEMF) ther- apy, compared to placebo, on the level of fatigue, walking performance, symptoms of depres- sion, and quality of life (QOL) in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: Forty-four adults with RRMS and minimal to significant disability were randomly assigned to a 4-week protocol using a PEMF or a placebo whole-body mat. The PEMF group were initially treated with 15Hz frequency, gradually increased to 30Hz (intensity between 25-35mT). The primary outcome was fatigue, assessed with the Fatigue Severity Scale (FSS) and the Modi- fied Fatigue Impact Scale (MFIS). Secondary measures included walking function (GAITRite sys- tem and Timed 25-Foot Walk test), the Beck Depression Inventory-II, and the Multiple Sclerosis International Quality of Life Questionnaire. Data were collected at baseline, after intervention, and at 3-months post-intervention (follow-up).
Results: There were no differences between groups for changes in fatigue symptoms from base- line to end of intervention (mean and 95% confidence interval FSS: -0.6, 95%CI: -1.3, 0.1; MFIS:
* Corresponding author at: Departamento de Fisioterapia, Facultad de Enfermería, Fisioterapia y Podología, Universidad de Sevilla, c/ Avi- cena s/n, 41009, Sevilla, Spain.
E-mail: carloslm@us.es (C. Luque-Moreno).
https://doi.org/10.1016/j.bjpt.2022.100449
1413-3555/© 2022 Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia. Published by Elsevier España, S.L.U. All rights reserved.
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