Cruising Review

PEMF Trigger Cell Death and Senescence in Cancer Cells


Bemer Review
Comprehensive review of Bemer and PEMF (Pulsed Electromagnetic Field). Explore scientific research, studies, and articles on the benefits and applications of Bemer and PEMF therapy for health and wellness.



Publication Title | PEMF Trigger Cell Death and Senescence in Cancer Cells

Health Web PEMF Search Series

Cruising Review Publications search was updated real-time via Filemaker on:

Cruising Review Publications | Return to Search List

Search Completed | Title | PEMF Trigger Cell Death and Senescence in Cancer Cells
Original File Name Searched: ijms-25-02473-v2.pdf | Google It | Yahoo | Bing


Previous Page | Next Page
pemf-trigger-cell-death-and-senescence-cancer-cells-001</TD> <TD valign=

Page | 001

International Journal of
Molecular Sciences
Article
Pulsed Electromagnetic Fields (PEMFs) Trigger Cell Death and Senescence in Cancer Cells
Pavlos Pantelis 1,†, Giorgos Theocharous 1,†, Dimitris Veroutis 1,‡, Ioanna-Aglaia Vagena 1,2,‡, Aikaterini Polyzou 1, Dimitris-Foivos Thanos 1, Efthymios Kyrodimos 3, Athanassios Kotsinas 1, Konstantinos Evangelou 1,
Nefeli Lagopati 1,2,4,*
, Vassilis G. Gorgoulis 1,4,5,6,7,* and Nicholas Kotopoulos 1
1
2
3
4 5 6
7
* Correspondence: nlagopati@med.uoa.gr (N.L.); vgorg@med.uoa.gr (V.G.G.); Tel.: +30-210-746-2362 (N.L.); +30-210-746-2352 (V.G.G.)
† ‡
Abstract: The currently available anti-cancer therapies, such as gamma-radiation and chemotherapeu- tic agents, induce cell death and cellular senescence not only in cancer cells but also in the adjacent normal tissue. New anti-tumor approaches focus on limiting the side effects on normal cells. In this frame, the potential anti-tumor properties of Pulsed Electromagnetic Fields (PEMFs) through the irradiation of breast cancer epithelial cells (MCF-7 and MDA-MB-231) and normal fibroblasts (FF95) were investigated. PEMFs had a frequency of 8 Hz, full-square wave type and magnetic flux density of 0.011 T and were applied twice daily for 5 days. The data collected showcase that PEMF application decreases the proliferation rate and viability of breast cancer cells while having the opposite effect on normal fibroblasts. Moreover, PEMF irradiation induces cell death and cellular senescence only in breast cancer cells without any effect in the non-cancerous cells. These findings suggest PEMF irradiation as a novel, non-invasive anti-cancer strategy that, when combined with senolytic drugs, may eliminate both cancer and the remaining senescent cells, while simultaneously avoiding the side effects of the current treatments.
Keywords: pulsed electromagnetic fields (PEMFs); cancer therapeutics; cell viability; cell death; senescence
1. Introduction
Cancer is one of the most prevalent causes of death worldwide. This entity represents a multifaceted disorder commonly characterized by heterogeneity [1]. Thus, complex treatments are required, while the continuous development of novel approaches that either eliminate or delay the growth of cancer cells comprises an imperative therapeutic goal [2].
Chemotherapy, radiation therapy [3], radionuclide therapy [4], immunotherapy and hormone therapies along with surgery are traditionally applied, solely or in combination, and are considered as powerful tools in our arsenal against cancer. As far as radiation therapy is concerned, ionizing irradiation [characterized by very low wavelength, high frequency and low linear energy transmission (LET)] [5] is conventionally utilized as the treatment of choice, resulting in the shrinkage or remission of tumors [6]. However,
Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens (NKUA), 11527 Athens, Greece
Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens (NKUA), 11527 Athens, Greece
1st ENT Department, Hippocration Hospital, National and Kapodistrian University of Athens (NKUA), 11527 Athens, Greece
Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece
Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M20 4GJ, UK
Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK
These authors contributed equally to this work, as first authors. These authors contributed equally to this work, as second authors.
Citation: Pantelis, P.; Theocharous, G.; Veroutis, D.; Vagena, I.-A.; Polyzou, A.; Thanos, D.-F.; Kyrodimos, E.; Kotsinas, A.; Evangelou, K.; Lagopati, N.; et al. Pulsed Electromagnetic Fields (PEMFs) Trigger Cell Death and Senescence in Cancer Cells. Int. J. Mol. Sci.2024,25,2473. https://doi.org/ 10.3390/ijms25052473
Academic Editor: Michael Welsh
Received: 20 January 2024 Revised: 10 February 2024 Accepted: 19 February 2024 Published: 20 February 2024
Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Int. J. Mol. Sci. 2024, 25, 2473. https://doi.org/10.3390/ijms25052473 https://www.mdpi.com/journal/ijms

Search Contact: greg@cruisingreview.com