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J. Clin. Med. 2020, 9, 1001 8 of 13 Table 3. Change in visual acuity outcomes; best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA) and low-luminance deficit (LLD). BCVA (ETDRS Letters) Baseline 1 Month 3 Months 6 Months 12 Months LLVA (ETDRS Letters) Baseline 1 Month 3 Months 6 Months 12 Months LLD (ETDRS Letters) Baseline 1 Month 3 Months 6 Months 12 Months Mean (SD); n iAMD with no SDD 84.8 (7.6); 15 85.9 (6.4); 15 86.0 (5.5); 15 84.8 (7.3); 13 85.7 (6.6); 15 Mean (SD); n iAMD with no SDD 70.8 (8.1); 15 68.6 (8.2); 15 70.3 (8.0); 15 69.5 (8.9); 13 67.2 (9.0); 15 Mean (SD); n iAMD with no SDD 14.0 (5.5); 15 17.3 (7.1); 15 15.7 (7.0); 15 15.3 (7.3); 13 18.5 (6.3); 15 Change from Baseline Mean (SE) Adjusted Difference Between Groups (95% CI) Healthy ageing 87.1 (6.5); 12 87.4 (7.2); 12 86.2 (8.8); 12 86.5 (6.3); 10 85.7 (6.4); 12 Healthy ageing 73.5 (6.0); 12 71.7 (7.0); 12 74.3 (7.2); 12 75.0 (6.1); 10 70.4 (6.2); 12 Healthy ageing 13.6 (3.7); 12 15.6 (5.8); 12 11.9 (5.7); 12 11.5 (3.9); 10 15.3 (4.3); 12 iAMD with SDD 81.6 (3.7); 8 84.1 (4.5); 8 83.1 (5.6); 7 84.2 (3.7); 6 83.0 (3.9); 8 iAMD with SDD 68.1 (6.3); 8 68.9 (6.5); 8 69.4 (7.7); 7 69.7 (8.4); 6 65.9 (8.7); 8 iAMD with SDD 13.5 (5.9); 8 15.3 (5.0); 8 13.7 (5.6); 7 14.5 (8.9); 6 17.1 (8.3); 8 Healthy ageing iAMD with no SDD iAMD with SDD iAMD with no SDD vs HA p-value iAMD- with SDD vs HA p-value ---- --- 0.33 1.13 2.50 (1.05) (0.93) (1.28) −0.92 1.20 1.42 (1.05) (0.93) (1.34) 0.57 0.89 1.40 (1.11) (0.98) (1.41) −1.42 0.87 1.38 (1.05) (0.93) (1.28) Change from baseline Mean (SE) Healthy ageing --- 0.80 (−1.97–3.58) 2.12 (−0.66–4.89) 0.32 (−2.58–3.22) 2.28 (−0.47–5.03) 0.569 0.134 0.829 0.104 2.17 0.192 (−1.10–5.43) 2.34 0.170 (−1.02–5.70) 0.84 0.640 (−2.69–4.37) 2.79 0.092 (−0.47–6.05) with with p-value 0.856 0.525 0.281 0.798 p-value no SDD SDD Adjusted difference between groups (95% CI) iAMD iAMD iAMD with no SDD vs HA - −0.37 (−4.35–3.62) −1.28 (−5.27–2.70) −2.30 (−6.50–1.90) −0.52 iAMD- with SDD vs HA −1.83 −2.20 (1.50) (1.34) 0.75 −0.53 (1.50) (1.34) 2.25 −0.05 (1.59) (1.40) −3.08 −3.60 (1.50) (1.34) 0.75 (1.84) 0.90 (1.92) 2.05 (2.02) −2.25 (1.84) -- 2.58 0.279 (−2.12–7.28) 0.15 0.950 (−4.69–4.98) −0.20 0.939 (−5.29–4.89) 0.83 0.726 (−4.50–3.47) Adjusted difference between groups Change from baseline Mean (SE) Healthy ageing --- (−3.87–5.53) (95% CI) iAMD iAMD iAMD with no SDD vs HA - 1.17 (−2.99–5.32) 3.40 (−0.76–7.56) 2.68 (−1.70–7.06) 2.80 (−1.36–6.96) iAMD with SDD vs HA with with p-value 0.580 0.108 0.229 0.185 P-value no SDD SDD 2.17 3.33 (1.57) (1.40) −1.67 1.73 (1.57) (1.40) −1.74 0.94 (1.66) (1.46) 1.67 4.47 (1.57) (1.40) 1.75 (1.92) 2.13 (1.92) −0.62 (2.10) 3.63 (1.92) -- −0.42 0.867 (−5.32–4.49) 3.79 0.128 (−1.11–8.69) 1.12 0.678 (−4.19–6.42) 1.96 0.431 (−2.94–6.86) iAMD = intermediate AMD; SDD = subretinal drusenoid deposits; HA=healthy ageing; BCVA = Best Corrected Visual Acuity; ETDRS = Early Treatment Diabetic Retinopathy Study; LLVA =low luminance visual acuity; LLD=low luminance deficit.PDF Image | 670 nm Photobiomodulation in Age-Related Macular Degeneration
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