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J. Clin. Med. 2020, 9, 1001 9 of 13 Table 4. Change in rod function outcome measures; scotopic threshold and rod-intercept time (RIT). Rod-Intercept Time (RIT, minutes) Mean (SD); n Change from Baseline Mean (SE) Adjusted Difference Between Groups (95% CI) Healthy ageing iAMD with no SDD iAMD with SDD iAMD Healthy with ageing no SDD iAMD with SDD iAMD with no SDD vs HA p-value iAMD with SDD vs HA p-value Baseline 10.67 14.52 20.00 - - - - - - - 1 Month 3 Months 6 Months 12 Months Scotopic Thresholds (dB) Baseline 1 Month 3 Months 6 Months 12 Months (6.09); 8 9.06 (5.33); 8 5.83 (3.33); 11 5.39 (2.60); 10 5.48 (2.40); 11 Healthy ageing 56.18 (2.94); 12 55.27 (3.23); 12 57.47 (2.32); 12 57.42 (1.93); 10 (6.41); 10 14.19 (6.08); 12 12.51 (6.89); 15 13.27 (6.42); 13 12.40 (5.64); 13 Mean (SD); n iAMD with no SDD 54.70 (4.60); 15 56.05 (4.01); 15 57.46 (3.10); 15 56.11 (3.73); 13 (0.00); 5 17.29 (4.36); 5 19.92 (0.22); 7 17.21 (4.36); 5 19.34 (1.61); 6 iAMD with SDD 54.92 (4.40); 8 54.85 (5.42); 8 55.58 (4.15); 7 54.84 (3.39); 6 −1.89 0.93 (1.72) (1.55) −5.61 −0.62 (1.74) (1.50) −6.37 −0.44 (1.77) (1.57) −5.80 −1.20 (1.74) (1.57) −0.42 (2.45) −0.27 (2.40) −3.93 (2.45) −0.46 (2.40) 2.82 0.227 (−1.78–7.42) 4.98 0.032 (0.43–9.54) 5.92 0.014 (1.24–10.61) 4.60 0.052 (−0.04–9.25) 1.47 0.625 (−4.47–7.40) 5.33 0.075 (−0.55–11.21) 2.44 0.422 (−3.56–8.43) 5.34 0.075 (−0.54–11.23) Change from baseline Mean (SE) Healthy ageing --- Adjusted difference between groups (95% CI) iAMD iAMD iAMD with no SDD vs HA iAMD with SDD vs HA with with p-value p-value no SDD SDD --- −0.91 1.36 (1.09) (0.98) 1.29 2.77 (1.09) (0.98) 1.21 1.89 (1.16) (1.02) −0.07 2.27 (1.34) (−0.63–5.18) 0.83 1.48 (1.40) (−1.42–4.39) 0.09 0.67 (1.47) (−2.39–3.73) 0.84 0.628 (−2.58–4.27) −0.46 0.797 (−3.97–3.06) −1.12 0.550 (−4.82–2.58) −2.76 0.114 (−6.18–0.67) 0.124 0.314 0.664 0.553 iAMD = intermediate AMD; SDD = subretinal drusenoid deposits; HA=healthy ageing. 57.95 (1.75); 12 55.58 (6.20); 15 53.93 (4.64); 8 1.77 0.89 (1.09) (0.98) −0.99 −0.87 (1.34) (−3.78–2.03)PDF Image | 670 nm Photobiomodulation in Age-Related Macular Degeneration
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