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Int. J. Mol. Sci. 2016, 17, 309 10 of 10 Conflicts of Interest: Hans Christian Wulf has consultant work for Galderma. Catharina M. Lerche, Ida M. Heerfordt, and Jakob Heydenreich declare no conflict of interest. References 1. Wiegell, S.R.; Wulf, H.C.; Szeimies, R.M.; Basset-Seguin, N.; Bissonnette, R.; Gerritsen, M.J.; Gilaberte, Y.; Calzavara-Pinton, P.; Morton, C.A.; Sidoroff, A.; et al. Daylight photodynamic therapy for actinic keratosis: An international consensus. J. Eur. Acad. Dermatol. Venereol. 2012, 26, 673–679. [CrossRef] [PubMed] 2. Rubel, D.M.; Spelman, L.; Murrell, D.F.; See, J.A.; Hewitt, D.; Foley, P.; Bosc, C.; Kerob, D.; Kerrouche, N.; Wulf, H.C.; et al. Daylight photodynamic therapy with methyl aminolevulinate cream as a convenient, similarly effective, nearly painless alternative to conventional photodynamic therapy in actinic keratosis treatment: A randomized controlled trial. Br. J. Dermatol. 2014, 171, 1164–1171. [CrossRef] [PubMed] 3. Morton, C.A.; Wulf, H.C.; Szeimies, R.M.; Gilaberte, Y.; Basset-Seguin, N.; Sotiriou, E.; Piaserico, S.; Hunger, R.E.; Baharlou, S.; Sidoroff, A.; et al. Practical approach to the use of daylight photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: A European consensus. J. Eur. Acad. Dermatol. Venereol. 2015, 29, 1718–1723. [CrossRef] [PubMed] 4. Wiegell, S.R.; Haedersdal, M.; Philipsen, P.A.; Eriksen, P.; Enk, C.D.; Wulf, H.C. Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study. Br. J. Dermatol. 2008, 158, 740–746. [CrossRef] [PubMed] 5. Wiegell, S.R.; Haedersdal, M.; Eriksen, P.; Wulf, H.C. Photodynamic therapy of actinic keratoses with 8% and 16% methyl aminolaevulinate and home-based daylight exposure: A double-blinded randomized clinical trial. Br. J. Dermatol. 2009, 160, 1308–1314. [CrossRef] [PubMed] 6. Wiegell, S.R.; Fabricius, S.; Stender, I.M.; Berne, B.; Kroon, S.; Andersen, B.L.; Mørk, C.; Sandberg, C.; Jemec, G.B.E.; Mogensen, M.; et al. A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp. Br. J. Dermatol. 2011, 164, 1083–1090. [CrossRef] [PubMed] 7. Wiegell, S.R.; Fabricius, S.; Heydenreich, J.; Enk, C.D.; Rosso, S.; Baumler W Baldursson, B.T.; Wulf, H.C. Weather conditions and daylight-mediated photodynamic therapy: Protoporphyrin IX-weighted daylight doses measured in six geographical locations. Br. J. Dermatol. 2013, 168, 186–191. [CrossRef] [PubMed] 8. Stender, I.M.; Wulf, H.C. Photodynamic therapy with 5-aminolevulinic acid in the treatment of actinic cheilitis. Br. J. Dermatol. 1996, 135, 454–456. [CrossRef] [PubMed] 9. Stender, I.M.; Wulf, H.C. Købner reaction induced by photodynamic therapy using δ-aminolevulinic acid. Acta Derm. Venereol. 1996, 76, 392–393. [PubMed] 10. Kellner, C.; Bauriedl, S.; Hollstein, S.; Reinhold, U. Simulated-daylight photodynamic therapy with BF-200 aminolaevulinic acid for actinic keratosis: Assessment of the efficacy and tolerability in a retrospective study. Br. J. Dermatol. 2015, 172, 1146–1148. [CrossRef] [PubMed] 11. Peng, Q.; Warloe, T.; Berg, K.; Moan, J.; Kongshaug, M.; Giercksky, K.E.; Nesland, J.M. 5-Aminolevulinic acid-based photodynamic therapy. Cancer 1997, 79, 2282–2308. [CrossRef] 12. Wiegell, S.R.; Heydenreich, J.; Fabricius, S.; Wulf, H.C. Continuous ultra-low-intensity artificial daylight is not as effective as red LED light in photodynamic therapy of multiple actinic keratoses. Photodermatol. Photoimmunol. Photomed. 2011, 27, 280–285. [CrossRef] [PubMed] 13. Nissen, C.V.; Philipsen, P.A.; Wulf, H.C. Protoporphyrin IX formation after topical application of methyl aminolaevulinate and BF-200 aminolaevulinic acid declines with age. Br. J. Dermatol. 2015, 173, 760–766. [CrossRef] [PubMed] 14. Heydenreich, J.; Wulf, H.C. Miniature Personal Electronic UVR Dosimeter with Erythema Response and Time-stamped Readings in a Wristwatch. Photochem. Photobiol. 2005, 81, 1138–1144. [CrossRef] [PubMed] © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).PDF Image | Alternatives to Outdoor Daylight for Photodynamic Therapy
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