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wan and Lin Dovepress Figure 3 Improvement in a 27-year-old woman with inflammatory papules on the face. (A) Before treatment (top row). (B) Three-month follow-up after one treatment of MAL-PDT with red light, ie, 200 J/cm2, and 180-minute incubation under occlusion (bottom row). Abbreviations: MAL, methyl aminolevulinate; PDT, photodynamic therapy. Table 2 Use of indole-3-acetic acid and photodynamic therapy in treatment of acne Reference Kwon et al187 2013 Huh et al188 2012 Jang et al32 2011 Na et al189 2011 Indication n Seborrheic 23 dermatitis Acne vulgaris 25 Acne vulgaris 34 Acne vulgaris 14 Type of trial Prospective, single- blind Prospective Prospective, single- blind, split-face Prospective, biopsies on nude mice as well Treatment regimen; session number (interval) IAA-PDT with green light (520 nm); 2× (1 week) IAA-PDT 15 minutes of occlusion, and green light for 15 minutes; 5× (1 week) IAA-PDT with green light (520 nm) on half of the face and ICG with near-infrared radiation (805 nm) on the other half; 5× (1 week) IAA-PDT with green light (520 nm); 3× (2 week) Results Sebum excretion significantly reduced at week 2 until week 6. Inflammatory and noninflammatory acne lesions were significantly decreased; sebum secretion and erythema were reduced; histopathologic reduction of inflammation. Inflammatory . noninflammatory acne lesions decreased; sebum secretion decreased; up to 3 months of follow-up for subjective satisfaction score; no statistically significant difference between the two treatments. Growth of Propionibacterium acnes and Staphylococcus aureus was significantly suppressed; treated skin showed destruction of follicular ostia epithelium; no significant difference between 4-hour and 30-minute incubation; inflammatory lesions and sebum secretion were reduced. Abbreviations: IAA, indole-3-acetic acid; ICG, indocyanine green; PDT, photodynamic therapy. 154 Clinical, Cosmetic and Investigational Dermatology 2014:7 submit your manuscript | www.dovepress.com DovepressPDF Image | applications of photodynamic therapy dermatology
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