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wan and Lin Dovepress investing in. The field of PDT will continue to expand as new photosensitizers emerge in the market. Finally, combination therapy, particularly with imiquimod, will be the new standard of care for PDT in patients with skin cancer. Disclosure The authors report no conflicts of interest in this work. References 1. Calzavara-Pinton P, Arisi M, Sereni E, Ortel B. A critical reappraisal of off-label indications for topical photodynamic therapy with aminolevulinic acid and methylaminolevulinate. Rev Recent Clin Trials. 2010;5(2):112–116. 2. Darlenski R, Fluhr JW. Photodynamic therapy in dermatology: past, present, and future. J Biomed Opt. 2013;18(6):061208. 3. Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3(5):380–387. 4. Chaves YN, Torezan LA, Niwa AB, Sanches Junior JA, Festa Neto C. Pain in photodynamic therapy: mechanism of action and management strategies. An Bras Dermatol. 2012;87(4):521–526. 5. 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