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Biphasic dose response in low level light therapy FIGURE 12. Dose response of illumination time found in a study of 810-nm laser to treat zymosan- induced arthritis in rats. Integrated curves of knee circumference versus time were compared. Three LLLT regimens were equally successful where the illumination time was either 100 minutes or 10 minutes, but the ineffective regimen only had a 1 minute illumination time. delivered at 50 mW/cm2 which took the comparatively short time of 1 minute to deliver. This observation led us to propose that the illumina- tion time was an important parameter in some LLLT applications. 5. POSSIBLE EXPLANATIONS FOR BIPHASIC DOSE RESPONSE IN LLLT The repeated observations that have been made of the biphasic dose response phenomenon in LLLT require some explanation. The natural assumption that is frequently made is, that if a small dose of red or near- infrared light produces a significant therapeutic effect, then a larger dose should produce an even more beneficial effect. This natural assumption is frequently not the case. We here propose three possible explanations for the existence of the biphasic dose response based upon mechanistic considerations outlined in section 2. 5.1. Excessive ROS As discussed in 2.5 the light mediated generation of reactive oxygen species has been observed in many in vitro studies and has been proposed to account for the cellular changes observed after LLLT via activation of redox sensitive transcription factors (Chen et al. 2009a). The evidence ofPDF Image | BIPHASIC DOSE RESPONSE IN LOW LEVEL LIGHT THERAPY
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