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Chapter 2: MATERIALS AND METHODS 2.1 Study design and approvals This study was reviewed and approved for scientific validity and methodology by the Dental Research Institute of the University of Toronto, Faculty of Dentistry. All protocols were approved by the University of Toronto, Research Ethics Board (approvals shown in Appendix A). This study has been registered at www.clinicaltrials.gov. 2.2 Patient selection Patients undergoing treatment at the University of Toronto, Faculty of Dentistry, Graduate Orthodontics clinic were recruited for the study. All participating patients were previously treatment planned by supervising certified specialists in orthodontics and required bilaterally symmetric extraction of first or second premolars. The following inclusion and exclusion criteria were applied: Inclusion criteria: • Age ≥ 11 years old • Fixed edgewise appliance therapy of all permanent teeth • Treatment planned for bilaterally symmetrical extraction of first or second premolar teeth • Presence of adequate residual extraction space size (after the correction of crowding) large enough to require more than 1 orthodontic appointment interval for complete space closure 16PDF Image | Effect of LED Phototherapy on the Rate of Orthodontic Tooth Movement
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