Effects of low-power light therapy on wound healing

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Effects of low-power light therapy on wound healing ( effects-low-power-light-therapy-wound-healing )

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Effects of low-power light therapy on wound healing: LASER x LED 619 Study Whelan et al.57 Vinck et al.58 Weiss et al.59 Huang et al.60 Lanzafame et al.61 Agnol et al.62 Tada et al.63 Komine et al.64 Meyer et al.65 Sousa et al.66 Adamskaya et al.67 Lim et al.68 Cheon et al.69 Fushimi et al.70 Study Vinck et al.70 Corazza et al.71 Volpato et al.72 Nishioka et al.73 Sampaio et al.74 Sousa et al.75 Model In vitro In vitro In vitro In vitro Mouse Rat In vitro In vitro Rat Rat Rat In vitro Rat In vitro Wavelength (nm) 670; 728; 880 570 590 630 670 640 627 627 515-525 620-630 460; 530; 700 470; 629 635 470; 525; 633 456; 518; 638 Dose (J/cm2) 4; 8 0.1 0.1 1; 2 5 6 1; 2; 4; 8; 10 4 --------- 10 --------- --------- --------- 0.2; 0.3; 0.6 Biological effects + + + + + + + + + + + + + + Biological effects + + + + + + TABLE 2: Biological effects of LED light on cutaneous wounds TABLE 3: Biological effects of LED and LASER light on cutaneous wounds Model In vitro Rat In vitro Rat Rat Rat Type of light LASER LED LASER LED LASER LED LASER LED LASER LED LASER LED Wavelength (nm) 830 570 660 950 660 635 660 780 637 660 630 660 700 660; 790 460; 530; 700 Dose (J/cm2) 1 0.1 0.53 0.53 5 20 4; 8 5; 10 4; 8 5 10 10 diodes convert the electrical current in a light spec- trum, a process called electroluminescence.79 LEDs usually operate with outputs in the range of milli- watts and therefore are usually set up on small chips or connected to small light bulbs.80 The variable characteristics and parameters of light devices is one of the factors that complicate the interpretation of research results about the effects of low intensity light on skin wounds. As observed in this study, there is discordance between the types of light and parameters used in studies. This fact may limit the decision-making process regarding the role of light in treating wounds since photobiomodulator effects are parameter-dependent. Energy absorption is the primary mechanism that allows light from LASER or LED to produce bio- logical effects in the tissue. Light absorption is depend- ent on wavelength and the main tissue chromophores (hemoglobin and melanin) strongly absorb wave- lengths shorter than 600 nm. For these reasons, there is a therapeutic window in the optical spectral range of red and near infrared, wherein the efficiency of light penetration in the tissue is maximum (Figure 1).81 Fifty-nine of the 68 studies reviewed applied LASER or LED inside the optical therapeutic window and 9 applied them in the range of blue or green, and even so biological effects were observed. Although light in the blue and green wavelengths range can An Bras Dermatol. 2014;89(4):616-23.

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