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CHAPTER 4 the SCI group (p = 0.0097, CLMM), however there was no time effect (p = 0.96) or treatment/time interaction (p = 0.79). To establish whether increases in sensitivity in SCI and SCI+670 groups were due to spinal cord injury but not the surgical procedures, two sham-injured groups were also included (sham-injured + untreated, shamSCI; sham-injured + 670 nm treated shamSCI+670) and subjected to the same sensitivity testing (Figure 4.1c). CSSs of shamSCI animals were not significantly different to those of the NIC group (p = 0.52, CLMM); however interestingly, the CSSs of the shamSCI+670 group were significantly reduced (p = 0.009). The shamSCI+670 group was also significantly reduced compared to the shamSCI group (p = 0.03, CLMM), there was a marginally significant effect of time (p = 0.052), however no treatment/time interaction (p = 0.76). Figure 4.1 Cumulative sensitivity is increased up to 7-dpi following mild T10 hemicontusion spinal cord injury but reduced after red light treatment. (a) RSSs in the NIC group (n=7) showing the mean + SEM, mean, and mean – SEM in concentric order as indicated by the colour scale and accompanying grey legend (insert). RSSs, obtained from six regions (left and right sides; “Above-Level”, “At-Level”, and “Below-Level” relative to T10 injury), are overlayed on a schematic representation of the rat dorsum, with C2, T1, L1 and S1 dermatomes and midline indicated (grey lines). Statistical comparison between levels is 85PDF Image | Effects of Red Light Treatment on Spinal Cord Injury
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