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CHAPTER 4 Approximate location of injury is indicated by the purple shaded area. (b) Example images are shown of positive GFAP labelling (green) from untreated and light-treated groups ipsilateral to the injury at the dorsal region at 3-dpi. (c-d) Quantification of GFAP positive labelling, expressed as the percentage area of positive label above threshold within the dorsal regions of interest contralateral (c) and ipsilateral (d) to the injury of untreated and light-treated groups. (e-f) GFAP positive label in the lateral regions of interest contralateral (e) and ipsilateral (f) to the injury. (g- h) GFAP positive label in the ventral regions of interest contralateral (g) and ipsilateral (h) to the injury. n values indicated (legend) are for each time point. Statistical comparisons between SCI and SCI+670 groups across all time points and regions (black bracket, LMER) and across the time points at individual region (black line, LMER) are indicated. Data is expressed as mean ± SEM; * p < 0.05, ** p < 0.01. See Figure 4.1 for abbreviations. As there was no difference in GFAP on the contralateral side between the two groups at the 1-dpi, the relative GFAP expression compared to normal animals was determined. Another age, sex and sibling matched cohort of animals were included: non-injured controls (NIC), sham-injured untreated (shamSCI), and spinal cord injured untreated (SCI). Their spinal cords were processed at 1-dpi and stained for GFAP+ expression (Figure 4.7). These experiments demonstrate that compared to non-injured (p < 2e-16) or sham-injured (p < 2e-16) animals, GFAP expression was significantly elevated across the entire cord within 24 hours following injury. The ipsilateral side was significantly increased only in the SCI group (p = 0.03) as seen in Figure 4.6 but this trend was not observed in NIC or shamSCI groups. In summary, these results demonstrate that the astrocyte reactivity was elevated across the entire spinal cord at the injury level following hemicontusion from 1-dpi, but more so on the ipsilateral side. GFAP expression is not affected by red light at 1-dpi, but is significantly supressed by 670 nm treatment from 3 to 7-dpi. 96PDF Image | Effects of Red Light Treatment on Spinal Cord Injury
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