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CHAPTER 4 density was elevated on the ipsilateral side compared to the contralateral side (p = 2.6e-07, LMER) and there was no overall significant effect of red light treatment (p = 0.28). Across the dorsal region (Figure 4.8c-d), there was a significant time effect (p = 0.033, LMER) but no treatment effect (p= 0.30): the contralateral side (Figure 4.8c) was elevated at the 3-dpi (p = 0.05) and 5-dpi (p = 0.05) after which it returned to the 1-dpi level by 7 days; the ipsilateral side (Figure 4.8d) was significantly elevated at 5-dpi only (p = 0.03 compared to both 1-dpi and 3-dpi). In the lateral (Figure 4.8d-e) and ventral (Figure 4.8f-g) regions, there was no difference between sides (p = 0.40) or time points (p = 0.42), however the lateral regions were significantly reduced compared to the dorsal regions (p = 0.02). In summary, these results indicate that IL1β expressing astrocytes are present throughout the spinal cord and peak at 5-dpi in the dorsal region only, following hemicontusion. While there is an overall suppression of GFAP, 670 nm red light treatment has no impact on the expression of IL1β producing astrocytes. 98PDF Image | Effects of Red Light Treatment on Spinal Cord Injury
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