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S.Y. Lee et al. / Journal of Photochemistry and Photobiology B: Biology 88 (2007) 51–67 57 a 125% 120% 115% 110% 105% 100% 95% 90% 85% 80% b 1.00 0.95 0.90 0.85 0.80 0.75 0.70 0.65 0.60 0.55 0.50 1.00 0.95 0.90 0.85 0.80 0.75 0.70 0.65 0.60 0.55 0.50 Before treatment Group 1 Group 2 Group 3 Group 4 Before treatment Week 2 Week 3 Group 1 Week 4 2 weeks post- treatment 4 weeks post- treatment 8 weeks post- treatment 12 weeks post- treatment 1.00 0.95 0.90 0.85 0.80 0.75 0.70 0.65 0.60 0.55 0.50 1.00 0.95 0.90 0.85 0.80 0.75 0.70 0.65 0.60 0.55 0.50 Group 2 Covered side Treated side Before treatment Week2 Week3 Week4 2weeks post- 4 weeks post- 8 weeks post- 12 weeks post- Before treatment Week 2 Week 3 Week 4 2 weeks post- 4 weeks post- 8 weeks post- 12 weeks post- treatment treatment treatment treatment treatment treatment treatment treatment Group 3 Group 4 Covered side Treated side Covered side Treated side Week 2 Week 3 Week 4 2 weeks post- 4 weeks post- 8 weeks post- 12 weeks post- Before treatment Week 2 Week3 Week 4 2 weeks post- 4 weeks post- 8 weeks post- 12 weeks post- treatment treatment treatment treatment treatment treatment treatment treatment Fig. 2. The elasticity of the skin (represented as net elasticity, R2 value) increased significantly in the treated sides of the treatment groups, which was not observed in the covered sides of all groups or in the treated sides of the control group. (a) Percentage increase of R2 values (net elasticity) in the treated sides of each group. (b) Comparison of R2 values between the treated sides and the covered sides within each group. Covered side Treated side shown by the high proportion of ‘good’ and ‘excellent’ in the three treatment groups versus the majority occupied by ‘no change’ in the control group (Fig. 3). A tendency for the satisfaction levels to get noticeably higher over time was noted, beginning 4 weeks after treatment completion. At the final assessment, group 1 (830 nm alone) and group 3 (830 nm and 633 nm) showed the greatest proportion of highly satisfied patients (those who answered as ‘good’ or ‘excellent’), of 95.2% (20 out of 21) and 95.5% (21 out of 22), respectively, which was considerably higher than that of group 2 (72.3%, 13 out of 18). In the control group, it was 13.3% at the last follow-up point. There was a particular case where a 55-year-old woman, who was included in group 1, expressed great satisfaction with a marked improvement of telangiectasia on her cheeks (Fig. 4), the mechanism for which remains speculative. No adverse effect was reported during the whole study period. The investigators’ global assessment is shown in Table 4. The score indicating the degree of improvement in wrinkle severity was higher in the treated sides of groups 1, 2, and 3 than in group 4. The average scores in the treatment groups were over 2, which indicated that there was more than ‘moderate improvement’ in these groups. However, in the control group, the scores were below 0.5 in both treatedPDF Image | LED phototherapy for skin rejuvenation
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