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NIH Public Access Author Manuscript Semin Cutan Med Surg. Author manuscript; available in PMC 2014 August 08. Published in final edited form as: Semin Cutan Med Surg. 2013 March ; 32(1): 41–52. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring Pinar Avci, MD1,2, Asheesh Gupta, PhD1,2,3, Magesh Sadasivam, MTech1,2,5, Daniela Vecchio, PhD1,2, Zeev Pam, MD4, Nadav Pam, MD4, and Michael R Hamblin, PhD1,2,5,* 1Wellman Center for Photomedicine, Massachusetts General Hospital, Boston MA 2Department of Dermatology, Harvard Medical School, Boston MA 3Defence Institute of Physiology & Allied Sciences, Delhi, India 4Aripam Medical Center, Ashdod, Israel 5Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA Abstract Low-level laser (light) therapy (LLLT) is a fast-growing technology used to treat a multitude of conditions that require stimulation of healing, relief of pain and inflammation, and restoration of function. Although the skin is the organ that is naturally exposed to light more than any other organ, it still responds well to red and near-infrared wavelengths. The photons are absorbed by mitochondrial chromophores in skin cells. Consequently electron transport, adenosine triphosphate (ATP) nitric oxide release, blood flow, reactive oxygen species increase and diverse signaling pathways get activated. Stem cells can be activated allowing increased tissue repair and healing. In dermatology, LLLT has beneficial effects on wrinkles, acne scars, hypertrophic scars, and healing of burns. LLLT can reduce UV damage both as a treatment and as a prophylaxis. In pigmentary disorders such as vitiligo, LLLT can increase pigmentation by stimulating melanocyte proliferation and reduce depigmentation by inhibiting autoimmunity. Inflammatory diseases such as psoriasis and acne can also benefit. The non-invasive nature and almost complete absence of side-effects encourages further testing in dermatology. Keywords Acne; Dermatology; Herpes; Laser; LLLT; Low level laser therapy; Phototherapy; Skin disease; Skin Rejuvenation; Pigmentation; Vitiligo © 2012 Elsevier Inc. All rights reserved. Correspondence Author: Michael R. Hamblin, PhD, Department of Dermatology Harvard Medical School, BAR 414 Wellman Center for Photomedicine Massachusetts General Hospital 40 Blossom Street Boston MA 02114 USA. Tel.: +1 617 726 6182; Fax: +1 617 726 8566. hamblin@helix.mgh.harvard.edu (M. R. Hamblin). Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure for Potential Conflicts of Interest and none were reported. Dr Gupta has received a grant from Boyscast Fellowship, Rolo-11, in India. All other authors have nothing to disclose. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptPDF Image | Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
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