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Avci et al. Page 22 Figure 4. Possible mechanism of actions for LLLT’s effects on skin rejuvenation. LLLT aids skin rejuvenation through increasing collagen production and decreasing collagen degradation. Increase in collagen production occurs by LLLT’s increasing effects on PDGF and fibroblast production which happens through decreasing apoptosis, increasing vascular perfusion, bFGF and TGF-β. Decrease in IL-6, and increase in TIMPs which in turn reduce MMPs all aid in reduction of collagen degradation. Semin Cutan Med Surg. Author manuscript; available in PMC 2014 August 08. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptPDF Image | Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
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