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244 IVANDIC AND IVANDIC TABLE 3. VISUAL ACUITY BEFORE AND AFTER LLLT IN PATIENTS WITH AMD WITH CATARACTS (N 182 EYES) Before therapy Visual 20/ 20/ 20/ 20/ 20/ 20/ 20/ 20/ 20/ 20/ 20/ Log 2 2 3 1 2 123 23 1342 122 12 2 2 4 1 16 15 1 1 2 13 7 14 1 4 5 32 4 10 3 1 1 6 8 11 15 8 5 35 28 49 14 3 1 3 1.00 0.70 0.60 0.55 0.50 0.40 0.30 0.20 0.10 0.50 0.10 After therapy acuity 400 200 100 80 70 20/400 20/200 20/100 20/80 20/70 20/60 20/50 20/40 20/30 20/25 20/20 20/16 Sums 60 50 40 30 25 20 MAR Sums 2 5 1 3 7 5 10 9 43 38 46 13 182 morphopsias, scotomas, and acquired dyschromatopsia (Fig. 4). In patients with wet AMD, edema and bleeding were re- duced. Safety and tolerability The treatment was well tolerated. No adverse local or sys- temic side effects were observed. Discussion LLLT given over 2 wk led to an improvement in visual acuity in most patients with AMD (90%). An increase of three to seven rows of optotypes was observed in 52/182 (28.6%) of eyes with cataracts, and in 59/146 (40.4%) of eyes without cataracts. Unlike other therapeutic approaches, LLLT improved visual acuity in patients with AMD of every Number of eyes are in bold type. log MAR, logarithmic minimal angle resolution. optotypes in 29/146 (19.8%), by two rows in 54/146 (37.0%), by three rows in 28/146 (19.2%), by four or five rows in 12/146 (8.2%), by six rows in 6/146 (4.1%) and by seven rows in 1/146 (0.7%). Visual acuity remained unchanged in 4/146 eyes (2.7%). In patients with cataracts (Table 3), visual acuity improved in 172/182 eyes (94.5%; p 0.00001) eyes: by one row of op- totypes in 45/182 (24.7%), by two rows in 75/182 (41.2%), by three rows in 25/182 (13.7%), by four rows in 16/182 (8.8%), by five rows in 7/182 (3.8%), by six rows in 3/182 (1.6%), and by seven rows in 1/182 (0.5%). Visual acuity re- mained unchanged in 10/182 eyes (5.5%). Changes in concomitant eye disorders In patients treated with LLLT the improvement in visual acuity was in most cases accompanied by a decrease in meta- FIG. 4. Normalization of impaired color vision in a 49-year-old patient. Farnsworth color test results (Series D-15) before (left) and after (right) four treatments with LLLT. Visual acuity increased from 20/30 to 20/16.PDF Image | Low-Level Laser Therapy Improves Vision in Macular Degeneration
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