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with aged/photoaged skin [10]. Profilometry quantification demonstrated that more than 90% of individuals had a reduction in rhytid depth and surface roughness, and, 87% of the individuals reported that they have experienced a reduction in the Fitzpatrick wrinkling severity score following 12 LLLT treatments [10]. Figure 1: Examples of LLLT devices used for skin rejuvenation. 2. LLLT for Treatment of Hair Loss: 2.1 Hair and Types of Hair Loss: Hair is amongst the fastest growing tissues of the body, undergoing repetitive and regenerative cyclical change, where each cycle consists of telogen (resting), anagen (active) and catagen (physiological involution) stages (Figure 2) [15]. During the transition from telogen to anagen there is stringent regulation of the activation of epithelial bulge stem cells and the transient amplifying (TA) progeny cells arise from the secondary hair germ cells [16]. Along the duration of the anagen phase, the TA cells display resilient proliferation within the epithelial matrix of the hair follicle. As a result, the end product of the hair cycle i.e. the bulk of the hair filament is formed through terminal differentiation of the proliferating trichocytes. The prime regulatory element of progenitor cell activation, hair matrix cell proliferation and terminal differentiation of trichocytes is believed to be the dermal papilla of the hair follicle [17]. III Figure 2: Stages of hair cycle Proc. of SPIE Vol. 8932 89320X-3 Al% cZes:PDF Image | Low-level light therapy (LLLT) for cosmetics and dermatology
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