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Nagaya et al. Published OnlineFirst June 6, 2017; DOI: 10.1158/1541-7786.MCR-17-0164 Figure 3. In vivo effect of NIR-PIT for PC3pip-luc tumor. A, NIR-PIT regimen. Fluorescence and bioluminescence images were obtained at each time point as indicated. B, In vivo fluorescence real-time imaging of tumor-bearing mice in response to NIR-PIT. The tumor treated by NIR-PIT showed decreasing IR700 fluorescence after NIR-PIT. C, In vivo BLI of tumor bearing mice in response to NIR-PIT. Before NIR-PIT, tumors were approximately the same size and exhibited similar BLI signals. The tumor treated by NIR-PIT showed decreasing luciferase activity after NIR-PIT. D, Quantitative luciferase activity (before NIR-PIT is set to 100) showed a significant decrease in NIR-PIT tumors (n ! 10, P < 0.001 vs. other groups, by Tukey test with ANOVA). Luciferase activity of tumor in other control groups showed an increase due to rapid tumor growth. E, Tumor growth was significantly inhibited in the NIR-PIT treatment group with anti-PSMA-IR700 (n ! 10; , P < 0.001 vs. other control groups, Tukey test with ANOVA). F, Significantly prolonged survival was observed in the NIR-PIT treatment group with anti-PSMA-IR700 (n ! 10; , P < 0.0001 vs. other control groups, by log-rank test). 1158 Mol Cancer Res; 15(9) September 2017 Molecular Cancer Research Downloaded from mcr.aacrjournals.org on December 1, 2020. © 2017 American Association for Cancer Research.PDF Image | Near-Infrared Photoimmunotherapy Targeting Prostate Cancer
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