PDF Publication Title:
Text from PDF Page: 007
nanoparticle treatment are concerns about the toxicity of the heavy metal content of the BRET-Qdots, which are yet to be fully alleviated. 1 Molecular Mechanisms of Photobiomodulation and their Implications for Alzheimer’s Disease The impact of photobiomodulation on cell culture and animal models of Alzheimer’s disease has been extensively studied. A summary of the progress on each stage of development from basic research to preclinical and clinical Phase I and II trials is presented to form the base for a treatment plan. 2..1.1 PBM and AD in vitro Sommer et al report that photobiomodulation reduces amyloid beta (Aβ25-35) aggregates in human neuroblastoma cells [28] and Yang et al observed a reduction in amyloid beta induced oxidative and inflammatory responses in rat primary cortical astrocytes [29]. Looking further at the implications of PBM on neuro-inflammatory pathways, Song et al observed the effects of He-Ne laser light (632.8 nm) at doses from 3 J/cm2 to 50 J/cm2 on central nervous system resident macrophages (Microglia) in human SH-SY5Y neuronal cells and conclude that 20 J/cm2 at intervals of 24 h was the optimal dose to attenuate cell death by reducing microglia-mediated neurotoxicity via the Src/Syk signaling pathways [30]. Liang et al and Zhang et al examined the pathways leading to cell apoptosis following Aβ25-35 aggregation on neuronally differentiated PC12 cells and observed that a treatment with low power light produced with a He-Ne Laser at 623.8 nm demonstrated a positive effect of PBM [31–33]. Zhang et al specifically report that PBM activates protein kinase B (PKB / Akt) at a dose of 2 J/cm2, which in turn promotes a series of anti-apoptotic effects such as the inhibition of translocation of the pro-apoptotic Yes-associated protein (YAP) from the cytoplasm to the nucleus [33]. PBM with a He-Ne Laser also appears to activate protein kinase C (PKC), thereby affecting downstream apoptotic proteins in a dose dependent manner [32]. Irradiation for 5 to 20min with an energy density of 0.52mW/cm2, Enengl, Dungel #neverforget – PBM vs AD: A Systematic Review Page 7 of 25PDF Image | Photobiomodulation Against Alzheimer’s Disease
PDF Search Title:
Photobiomodulation Against Alzheimer’s DiseaseOriginal File Name Searched:
photobiomodulation-against-alzheimers.pdfDIY PDF Search: Google It | Yahoo | Bing
Cruise Ship Reviews | Luxury Resort | Jet | Yacht | and Travel Tech More Info
Cruising Review Topics and Articles More Info
Software based on Filemaker for the travel industry More Info
The Burgenstock Resort: Reviews on CruisingReview website... More Info
Resort Reviews: World Class resorts... More Info
The Riffelalp Resort: Reviews on CruisingReview website... More Info
CONTACT TEL: 608-238-6001 Email: greg@cruisingreview.com (Standard Web Page)