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[52–61]. The pathophysiological assessment with MRI at the start of the study is useful to support the diagnosis of early AD. A second MRI at the end of the treatment period might provide more useful in combination with a sensitive algorithm that can reliably detect a change in brain atrophy, for example the automated MRI assessment by Desikan et al which has already demonstrated its usefulness as a diagnostic marker for mild cognitive impairment (MCI) and AD [62]. 3 Conclusion When comparing the specifications of PBM devices used in the available literature, especially wavelength and intensity, a very inhomogeneous picture is created. One thing that is clear, however, is that the optical window for deep tissue penetration suggests best results at wavelengths in the far red and near infrared range, e.g. at 810 nm. The irradiation intensity of such a device needs to allow delivery of a dose of up to 60 J/cm2 to the scalp within a reasonable period of time while providing an energy density below the risk of thermal damage. The amalgamation of the available literature as presented in this systematic review allows the assumption that photobiomodulation with the right settings can be a useful tool in the fight against Alzheimer’s disease. Study protocols for large placebo-controlled studies are readily available and we should be able to get significant results with representative statistical power within a year. The time to act is now – lest we forget. 4 Acknowledgements This study was supported by FFG Basisprogramm grant #853128. Enengl, Dungel #neverforget – PBM vs AD: A Systematic Review Page 16 of 25PDF Image | Photobiomodulation Against Alzheimer’s Disease
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