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ACCEPTED MANUSCRIPT nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury. PloS one 9, e104565. Gkotsi, D., Begum, R., Salt, T., Lascaratos, G., Hogg, C., Chau, K.Y., Schapira, A.H., Jeffery, G., 2014. Recharging mitochondrial batteries in old eyes. Near infra-red increases ATP. Experimental eye research 122, 50-53. Grigsby, J.G., Cardona, S.M., Pouw, C.E., Muniz, A., Mendiola, A.S., Tsin, A.T.C., Allen, D.M., Cardona, A.E., 2014. The Role of Microglia in Diabetic Retinopathy. J Ophthalmol. Hamblin, M.R., 2016. Photobiomodulation or low-level laser therapy. Journal of biophotonics 9, 1122-1124. Herranz-Aparicio, J., Vazquez-Delgado, E., Arnabat-Dominguez, J., Espana-Tost, A., Gay-Escoda, C., 2013. The use of low level laser therapy in the treatment of temporomandibular joint disorders. Review of the literature. Medicina oral, patologia oral y cirugia bucal 18, e603-612. Hicks, D., Courtois, Y., 1990. The growth and behaviour of rat retinal Muller cells in vitro. 1. An improved method for isolation and culture. Experimental eye research 51, 119-129. Hu, D., Zhu, S., Potas, J.R., 2016. Red LED photobiomodulation reduces pain hypersensitivity and improves sensorimotor function following mild T10 hemicontusion spinal cord injury. Journal of neuroinflammation 13, 200. Jager, R.D., Mieler, W.F., Miller, J.W., 2008. Age-related macular degeneration. The New England journal of medicine 358, 2606-2617. Karu, T., 1999. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. Journal of photochemistry and photobiology. B, Biology 49, 1-17. Karu, T.I., 2008. Mitochondrial signaling in mammalian cells activated by red and near-IR radiation. Photochemistry and photobiology 84, 1091-1099. Kataoka, K., Matsumoto, H., Kaneko, H., Notomi, S., Takeuchi, K., Sweigard, J.H., Atik, A., Murakami, Y., Connor, K.M., Terasaki, H., Miller, J.W., Vavvas, D.G., 2015. Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell death & disease 6, e1731. Kauppinen, A., Paterno, J.J., Blasiak, J., Salminen, A., Kaarniranta, K., 2016. Inflammation and its role in age-related macular degeneration. Cellular and molecular life sciences : CMLS 73, 1765-1786. Kaynezhad, P., Tachtsidis, I., Jeffery, G., 2016. Optical monitoring of retinal respiration in real time: 670 nm light increases the redox state of mitochondria. Experimental eye research 152, 88-93. Knickelbein, J.E., Chan, C.C., Sen, H.N., Ferris, F.L., Nussenblatt, R.B., 2015. Inflammatory Mechanisms of Age-related Macular Degeneration. International ophthalmology clinics 55, 63-78. Kokkinopoulos, I., 2013a. 670 nm LED ameliorates inflammation in the CFH(-/-) mouse neural retina. Journal of photochemistry and photobiology. B, Biology 122, 24-31. Kokkinopoulos, I., Colman, A., Hogg, C., Heckenlively, J., Jeffery, G., 2013b. Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential. Neurobiology of aging 34, 602-609. Lu, Q., Jiang, Y.R., Qian, J., Tao, Y., 2013. Apelin-13 regulates proliferation, migration and survival of retinal Muller cells under hypoxia. Diabetes research and clinical practice 99, 158-167. Ma, W., Cojocaru, R., Gotoh, N., Gieser, L., Villasmil, R., Cogliati, T., Swaroop, A., Wong, W.T., 2013. Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation. Neurobiology of aging 34, 2310-2321. Marco, F.D., Romeo, S., Nandasena, C., Purushothuman, S., Adams, C., Bisti, S., Stone, J., 2013. The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina. American journal of neurodegenerative disease 2, 208-220. Nakazawa, T., Takeda, M., Lewis, G.P., Cho, K.S., Jiao, J., Wilhelmsson, U., Fisher, S.K., Pekny, M., Chen, D.F., Miller, J.W., 2007. Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin. Investigative ophthalmology & visual science 48, 2760-2768. Natoli, R., Fernando, N., Jiao, H., Racic, T., Madigan, M., Barnett, N.L., Chu-Tan, J.A., Valter, K., Provis, J., Rutar, M., 2017a. Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration. Investigative ophthalmology & visual science 58, 2977- 2990. 23 ACCEPTED MANUSCRIPTPDF Image | Photobiomodulation with 670 nm light ameliorates retinal
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