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ACCEPTED MANUSCRIPT Natoli, R., Fernando, N., Madigan, M., Chu-Tan, J.A., Valter, K., Provis, J., Rutar, M., 2017b. Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration. Molecular Neurodegeneration 12, 31. Natoli, R., Rutar, M., Lu, Y.Z., Chu-Tan, J.A., Chen, Y., Saxena, K., Madigan, M., Valter, K., Provis, J.M., 2016. The Role of Pyruvate in Protecting 661W Photoreceptor-Like Cells Against Light- Induced Cell Death. Current eye research 41, 1473-1481. Netea, M.G., van de Veerdonk, F.L., van der Meer, J.W., Dinarello, C.A., Joosten, L.A., 2015. Inflammasome-independent regulation of IL-1-family cytokines. Annual review of immunology 33, 49-77. Nita, M., Grzybowski, A., 2016. The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults. Oxidative medicine and cellular longevity 2016, 3164734. Rutar, M., Natoli, R., Chia, R.X., Valter, K., Provis, J.M., 2015. Chemokine-mediated inflammation in the degenerating retina is coordinated by Muller cells, activated microglia, and retinal pigment epithelium. Journal of neuroinflammation 12. Rutar, M., Natoli, R., Provis, J.M., 2012. Small interfering RNA-mediated suppression of Ccl2 in Muller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration. Journal of neuroinflammation 9, 221. Rutar, M., Natoli, R., Valter, K., Provis, J.M., 2011a. Early focal expression of the chemokine Ccl2 by Muller cells during exposure to damage-inducing bright continuous light. Investigative ophthalmology & visual science 52, 2379-2388. Rutar, M., Natoli, R., Valter, K., Provis, J.M., 2011b. Early focal expression of the chemokine Ccl2 by Muller cells during exposure to damage-inducing bright continuous light. Invest Ophthalmol Vis Sci 52, 2379-2388. Rutar, M., Provis, J.M., Valter, K., 2010. Brief exposure to damaging light causes focal recruitment of macrophages, and long-term destabilization of photoreceptors in the albino rat retina. Current eye research 35, 631-643. Schroder, K., Tschopp, J., 2010. The inflammasomes. Cell 140, 821-832. Schroeder, P., Pohl, C., Calles, C., Marks, C., Wild, S., Krutmann, J., 2007. Cellular response to infrared radiation involves retrograde mitochondrial signaling. Free Radical Bio Med 43, 128-135. Smiley, S.T., Reers, M., Mottola-Hartshorn, C., Lin, M., Chen, A., Smith, T.W., Steele, G.D., Jr., Chen, L.B., 1991. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J- aggregate-forming lipophilic cation JC-1. Proceedings of the National Academy of Sciences of the United States of America 88, 3671-3675. Tang, J., Du, Y., Lee, C.A., Talahalli, R., Eells, J.T., Kern, T.S., 2013. Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: in vivo and in vitro. Investigative ophthalmology & visual science 54, 3681-3690. Tarallo, V., Hirano, Y., Gelfand, Bradley D., Dridi, S., Kerur, N., Kim, Y., Cho, Won G., Kaneko, H., Fowler, Benjamin J., Bogdanovich, S., Albuquerque, Romulo J.C., Hauswirth, William W., Chiodo, Vince A., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Chaudhuri, G., Murphy, Michael P., Dunaief, Joshua L., Ambati, Balamurali K., Ogura, Y., Yoo, Jae W., Lee, D.-k., Provost, P., Hinton, David R., Núñez, G., Baffi, Judit Z., Kleinman, Mark E., Ambati, J., 2012. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149, 847-859. Taylor, L., Arnér, K., Ghosh, F., 2015. First responders: Dynamics of pre-gliotic müller cell responses in the isolated adult rat retina. Current eye research 40, 1245-1260. Tseng, W.A., Thein, T., Kinnunen, K., Lashkari, K., Gregory, M.S., D'Amore, P.A., Ksander, B.R., 2013. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Investigative ophthalmology & visual science 54, 110-120. Verardo, M.R., Lewis, G.P., Takeda, M., Linberg, K.A., Byun, J., Luna, G., Wilhelmsson, U., Pekny, M., Chen, D.F., Fisher, S.K., 2008. Abnormal reactivity of muller cells after retinal detachment in mice deficient in GFAP and vimentin. Investigative ophthalmology & visual science 49, 3659-3665. Walker, R.J., Steinle, J.J., 2007. Role of beta-adrenergic receptors in inflammatory marker expression in Muller cells. Investigative ophthalmology & visual science 48, 5276-5281. 24 ACCEPTED MANUSCRIPTPDF Image | Photobiomodulation with 670 nm light ameliorates retinal
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