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Photosensitizers for Anticancer Photodynamic Therapy

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Photosensitizers for Anticancer Photodynamic Therapy ( photosensitizers-anticancer-photodynamic-therapy )

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Molecules 2018, 23, 1436 13 of 13 21. Tang, Y.; Lee, D.; Wang, J.; Li, G.; Yu, J.; Lin, W.; Yoon, J. Development of fluorescent probes based on protection-deprotection of the key functional groups for biological imaging. Chem. Soc. Rev. 2015, 44, 5003–5015. [CrossRef] [PubMed] 22. Chen, S.; Zhao, X.; Chen, J.; Chen, J.; Kuznetsova, L.; Wong, S.S.; Ojima, I. Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release. Bioconjug. Chem. 2010, 21, 979–987. [CrossRef] [PubMed] 23. Gülmez, A.D.; Göksel, M.; Durmus ̧, M.J. Silicon(IV) phthalocyanine-biotin conjugates: Synthesis, photophysicochemical properties and in vitro biological activity for photodynamic therapy. Porphyr. Phthalocyanines 2017, 21, 547–554. [CrossRef] 24. Li, K.; Qiu, L.; Liu, Q.; Lv, G.; Zhao, X.; Wang, S.; Lin, J. Conjugate of biotin with silicon(IV) phthalocyanine for tumor-targeting photodynamic therapy. J. Photochem. Photobiol. B 2017, 174, 243–250. [CrossRef] [PubMed] 25. Shervington, L.A.; Smith, N.; Norman, E.; Ward, T.; Phillips, R.; Shervington, A. To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines. Eur. J. Med. Chem. 2009, 44, 2944–2951. [CrossRef] [PubMed] 26. Song, J.L.; Zhang, J.; Liu, C.L.; Liu, C.; Zhu, K.K.; Yang, F.F.; Liu, X.G.; Figueiró Longo, J.P.; Alexandre Muehlmann, L.; Azevedo, R.B.; et al. Design and synthesis of pregnenolone/2-cyanoacryloyl conjugates with dual NF-κB inhibitory and anti-proliferative activities. Bioorg. Med. Chem. Lett. 2017, 27, 4682–4686. [CrossRef] [PubMed] 27. Mohareb, R.M.; El-Sayed, N.N.; Abdelaziz, M.A. The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: Synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines. Steroids 2013, 78, 1209–1219. [CrossRef] [PubMed] 28. Szalóki, G.; Pantzou, A.; Prousis, K.C.; Mavrofrydi, O.; Papazafiri, P.; Calogeropoulou, T. Design and synthesis of 21-alkynylaryl pregnenolone derivatives and evaluation of their anticancer activity. Bioorg. Med. Chem. 2014, 22, 6980–6988. [CrossRef] [PubMed] 29. Takakusa, H.; Kikuchi, K.; Urano, Y.; Sakamoto, S.; Yamaguchi, K.; Nagano, T. Design and Synthesis of an Enzyme-Cleavable Sensor Molecule for Phosphodiesterase Activity Based on Fluorescence Resonance Energy Transfer. J. Am. Chem. Soc. 2002, 124, 1653–1657. [CrossRef] [PubMed] 30. Fan, J.; Dong, H.; Hu, M.; Wang, J.; Zhang, H.; Zhu, H.; Sun, W.; Peng, X. Fluorescence imaging lysosomal changes during cell division and apoptosis observed using Nile Blue based near-infrared emission. Chem. Commun. 2014, 50, 882–884. [CrossRef] [PubMed] 31. Garland, M.J.; Cassidy, C.M.; Woolfson, D.; Donnelly, R.F. Designing photosensitizers for photodynamic therapy: Strategies, challenges and promising developments. Future Med. Chem. 2009, 1, 667–691. [CrossRef] [PubMed] 32. Fernandez, J.M.; Bilgin, M.D.; Grossweiner, L.L. Singlet oxygen generation by photodynamic agents. J. Photochem. Photobiol. B 1997, 37, 131–140. [CrossRef] 33. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55. [CrossRef] Sample Availability: Samples of the compounds PS1–PS5 are available from the authors. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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