PDF Publication Title:
Text from PDF Page: 001
Photomedicine and Laser Surgery Volume 30, Number 9, 2012 a Mary Ann Liebert, Inc. Pp. 551–558 DOI: 10.1089/pho.2011.3186 A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer Max Myakishev-Rempel, Ph.D.,1 Istvan Stadler, Ph.D.,2 Philip Brondon, M.D.,2 David R. Axe, M.Sc.,1 Mark Friedman, Ph.D.,3 Frances Barg Nardia, M.Sc.,1 and Raymond Lanzafame, M.D., M.B.A.2 Abstract Objective: Red light phototherapy is known to stimulate cell proliferation in wound healing. This study in- vestigated whether low-level light therapy (LLLT) would promote tumor growth when pre-existing malignancy is present. Background data: LLLT has been increasingly used for numerous conditions, but its use in cancer patients, including the treatment of lymphedema or various unrelated comorbidities, has been withheld by practitioners because of the fear that LLLT might result in initiation or promotion of metastatic lesions or new primary tumors. There has been little scientific study of oncologic outcomes after use of LLLT in cancer patients. Methods: A standard SKH mouse nonmelanoma UV-induced skin cancer model was used after visible squa- mous cell carcinomas were present, to study the effects of LLLT on tumor growth. The red light group (n = 8) received automated full body 670 nm LLLT delivered twice a day at 5 J/cm2 using an LED source. The control group (n = 8) was handled similarly, but did not receive LLLT. Measurements on 330 tumors were conducted for 37 consecutive days, while the animals received daily LLLT. Results: Daily tumor measurements demonstrated no measurable effect of LLLT on tumor growth. Conclusions: This experiment suggests that LLLT at these parameters may be safe even when malignant lesions are present. Further studies on the effects of photo- irradiation on neoplasms are warranted. Introduction Low-level light therapy (LLLT) is being used increas- ingly for the treatment of a variety of conditions including trauma, wound healing, arthritis, musculoskeletal disorders, and dental and cosmetic applications.1–4 The current ther- apeutic approach is to be cautious of potential harmful effects from the use of LLLT in patients with cancer. Its use for the management of lymphedema and other com- plications in cancer patients has been withheld because of the fear that LLLT might promote metastasis.5,6. This ap- proach is summarized by the review of Hawkins et al., which stated that ‘‘LLLT should be avoided or given with special caution in.patients with cancer if there is any doubt of a recurrence of metastases..Although LLLT has not induced cancer in any of the reported studies, the precise reactions of existing tumors to LLLT are un- known.’’6 There is little scientific evidence available as re- gards oncologic outcomes and local responses to LLLT in cancer patients. Although it is unlikely that LLLT would induce de novo cancer development as there is no evidence that LLLT causes DNA damage, its effects on cellular proliferation have been the empiric basis for withholding treatment in cancer patients. Red light is known to have a mitogenic effect based on its ability to activate cell division at certain spectral and dose ranges in vitro.7–9 We are aware only of two studies on the effects of LLLT on cancer.10,11 Revazova demonstrated the acceleration of tumor growth by 633 nm laser irradiation at 3.5 J/cm2 three times per week for 2 weeks in a model of human gastric adenocarcinoma transplanted into immuno- deficient athymic nude mice.11 This suggests that LLLT is indeed capable of activating tumor growth under conditions that exclude immune resistance. In another study, the irra- diation of squamous cell carcinomas (SCC) in the hamster cheek pouch with 660 nm light at 56 J/cm2 and a 3 mm spot caused significant progression of the severity of SCC as judged by histology.10 The bulk of literature on the topic of LLLT and cancer does not address the question of LLLT ef- fects on tumor growth. 1Department of Dermatology, University of Rochester, Rochester, New York. 2Rochester General Hospital Laser Surgical Research Laboratory, Rochester, New York. 3Mathematical Sciences Department, University of Alabama in Huntsville, Huntsville, Alabama. 551PDF Image | Preliminary Study of the Safety of Red Light Phototherapy Cancer
PDF Search Title:
Preliminary Study of the Safety of Red Light Phototherapy CancerOriginal File Name Searched:
phototherapy-for-cancer.pdfDIY PDF Search: Google It | Yahoo | Bing
Cruise Ship Reviews | Luxury Resort | Jet | Yacht | and Travel Tech More Info
Cruising Review Topics and Articles More Info
Software based on Filemaker for the travel industry More Info
The Burgenstock Resort: Reviews on CruisingReview website... More Info
Resort Reviews: World Class resorts... More Info
The Riffelalp Resort: Reviews on CruisingReview website... More Info
| CONTACT TEL: 608-238-6001 Email: greg@cruisingreview.com | RSS | AMP |