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notice that they feel fatigued if they overdo it. And as an ill person is much less tolerant, their body may have a lower threshold for overdoing it compared to the younger, healthier person. So for anyone who is in very poor health (especially those who are easily overwhelmed by any type of stress or physical activity), it is very important to start with very low doses (i.e. at the bottom of my recommendations, or even lower), to make sure that your body can tolerate it. Then slowly increase the dose over the subsequent days and weeks to find the appropriate dose for you within the range outlined above. Can You Overdose on Red/NIR Light Therapy? (The Biphasic Dose Response) As I mentioned, there is something called the biphasic dose response. But what does that mean? That means that too little red/NIR light therapy won’t provide much, if any, benefit, and too much will also negate the benefit. In other words, it’s important to get the dose right and to be in the range I’m recommending. You aren’t doing yourself any favors by dosing higher than my guidelines suggest. The principle of the biphasic dose response is often explained as the Arndt-Schulz law, which dates back to the end of the nineteenth century, when H. Schulz analyzed the activity of various kinds of poisons like bromine, iodine, mercury, arsenic, etc. on yeast, where he showed that in very low doses, all of these poisons actually had a slightly stimulatory effect on the yeast metabolism. With the help of psychiatrist R. Arndt, they developed the concept (that later became the Arndt-Schulz law) which states that weak stimuli slightly increase metabolic activity, stronger stimuli increase it even more until a peak is reached, and from there, increasing the dose further suppresses the effect until a negative/harmful effect is eventually reached. Later, this concept became known as “hormesis” (which I discussed earlier.) The term “biphasic dose response” is also used. In the context of light therapy, Hamblin et al. describe it this way: “Simply put, it suggests that if insufficient energy is applied, there will be no response (because the minimum threshold has not been met), and if more energy is applied, then a threshold is crossed and biostimulation is achieved. However, when too much energy is applied, then the stimulation disappears and is replaced by bioinhibition.”368 In fact, Hamblin believes that in instances where studies don’t find significantly positive effects, it’s almost always because they did too large of a dose. One other important aspect here is that it’s much easier to do too large of doses on surface issues (like the skin) than it is for deeper tissues. The optimal doses for the skin can be reached within seconds or a few minutes with many devices, and it is very easy for people to use devices for two or three times longer than is ideal – often times, with people thinking that doing more will lead to better results – and they actually negate the benefits in the process. Although this idea might sound odd at first, there are many common examples where we know this occurs. One example is physical exercise. In small or moderate doses, it is clearly linked with countless health benefits. But we also know that people who over-exercise can actually cause themselves a great deal of harm. It’s not uncommon to hear of ultramarathon runners dropping dead from heart attacks, or developing calcification of arteries in the heart, or of female athletes over-exercising themselves into losing their menstrual cycle and fertility (hypothalamic amenorrhea). And of course, anyone who hasPDF Image | Red Light Therapy Ultimate Guide
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