THE USE OF NASA LED NEAR-INFRARED TECHNOLOGY FOR BIOSTIMULATION

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THE USE OF NASA LED NEAR-INFRARED TECHNOLOGY FOR BIOSTIMULATION ( the-use-nasa-led-near-infrared-technology-for-biostimulation )

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References Karu T., “Primary and secondary mechanisms of action of visible to near-IR radiation on cells.” J. Photochem. Photobiol. B. Biol. 49,1-7 (1999). Sommer A.P., Pinheiro A.L., Mester A.R., Franke R.P., Whelan H.T. "Biostimulatory windows in low intensity laser activation: Lasers, scanners and NASA's light emitting diode array system." Journal of Clinical Laser Medicine & Surgery 19, 27-33 (2001). Whelan H.T., Houle J.M., Donohoe D.L., Bajic D.M., Schmidt M.H., Reichert K.W., Weyenberg G.T., Larson D.L., Meyer G.A., Caviness J.A., “Medical Applications of Space Light-Emitting Di- ode Technology-Space Station and Beyond.” Space Tech. & App. Int’l. Forum 458, 3-15 (1999). Whelan H.T., Houle J.M., Whelan, N. T., Donahue, D. L., Cwiklinski, J., Schmidt, M. H., Gould, L., Larson, D. L., Meyer, G. A., Cevenini, V., and Stinson, H."The NASA Light-Emitting Diode Medical Program- Progress in Space Flight and Terrestrial Applications.” Space Tech. & App. Int’l. Forum 504, 37-43 (2000). Whelan H.T., Buchmann E.V., Whelan N.T., Turner S.G., Cevenini V., Stinson H., Ignatius R., Martin T., Cwiklinski J., Meyer G.A., Hodgson B., Gould L., Kane M., Chen G., Caviness J. "NASA light emitting diode medical applications: From deep space to deep sea." Space Tech. & App. Int'l Forum 552, 35-45 (2001). Whelan HT, Smits RL, Buchmann EV, Whelan NT, Turner SG, Margolis DA, Cevenini V, Stinson H, Ignatius R, Martin T, Cwiklinski J, Philippi AF, Graf WR, Hodgson B, Gould L, Kane M, Chen G, Caviness J: Effect of NASA Light-Emitting Diode (LED) Irradiation on Wound Heal- ing. Journal of Clinical Laser Medicine and Surgery. 19, 305-314 (2001). Acknowledgments The authors wish to thank Quantum Devices and NASA Marshall Space Flight Center SBIR Program for providing us with the LED array. This work was supported by grants from NASA Marshall Space Flight Center NAS8-01166 and NASA NAS8-99015. 39 Figure 14: Change in basic fi- broblast growth factor (FGF-2) concentration (μg/mg protein) vs. time (days) in rat ischemic wound model.

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