Therapeutic Uses of Red Macroalgae

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Therapeutic Uses of Red Macroalgae ( therapeutic-uses-red-macroalgae )

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Molecules 2020, 25, 4411 9 of 14 Figure 4. TLC qualitative AChEI assay. PC: +ve control, physostigmine (0.03 μg). DCM/MeOH extracts (100 μg) of (1) Hypnea musciformis, (2) Pterocladia capillacea, and (3) Ochtodes secundiramea. TLC elution system: hexane:ethyl acetate:methanol (2:7:1 v/v/v) [89]. The alcoholic extract of Gracilaria corticata (IC50 9.5) and G.; salicornia (IC50 8.7 mg/mL) extracts showed moderate AChEI efficiency [90]. The sulfated polysaccharides from Gelidium pristoides exhibited inhibitory potency on acetylcholinesterase that related to their antioxidant and neuroprotective potentials [91]. Some red seaweed species synthesize homotaurine, aminosulfonate compounds, which could be a promising medicine for Alzheimer’s disease prevention [92]. 13. Macroalgae for Skincare Macroalgae metabolites reduced the appearance of redness and blemishes, the appearance of sun damage, brightening, re-mineralizing, hydrating and firming skin [93]. They have a reaction mechanism toward the hazardous ultraviolet ‘UV-A and -B’ impacts via delivering phenolic compounds, mycosporine, amino acid, and carotenoids, which act as UV-absorbing [94]. The extracts of red seaweed Asparagopsis armata, Gelidium corneum, Corallina officinalis had skin softness, whitening/lightening, and elasticity restoring anti-aging properties so they can be used as skincare products including creams, oil, soap, mask, or lotion [95]. Agarose from Gracilaria cornea and G.; lemaneiformis are used for skin whitening, due to its anti-melanogenic activity by inhibiting melanin synthesis [96,97]. Fatty acid-like palmitic acid and its derivated ascorbyl palmitate from seaweed are used in cosmetics as emulsifiers and antioxidant agents for anti-wrinkle and anti-aging characteristics [98]. Amino acid extracted from Asparagopsis armata is inserted in some anti-aging lotions [37]. Mycosporine from different Rhodophyta species act as photoprotective substances for skin care products with antioxidant properties [3]. 14. Conclusions This review aims to provide an overview of some medical and cosmetic importance of red macroalgae. They represent renewable biomass and are a potentially fruitful source of vital bioactive compounds that ecofriendly and safe. These bioactive compounds are already used mainly in food and medicine. For example, sulfated polysaccharides from red algae are commercially applied as a useful ingredient as a thickening agent, stabilizer, emulsifier, texture modifier, and dietary fiber in food and pharmaceutical industries. There are some species from Rhodophyta whose feasibility medical potential is higher, like Gracilaria spp., Pterocladia spp. Jania spp. and Corallina spp. Due to the economic importance of seaweed, more studies should be undertaken, focusing on improving seaweed production on a large scale by adjusting the culture conditions. Cultivation of economic species in seaweed aquaculture may be the future road for the sustainability of seaweed and controlling the production of active compounds. Optimization extraction methods, purification, and fractionation

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