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Molecules 2020, 25, 4411 10 of 14 of bioactive compounds led to the production of more active and safe compounds. Therefore, more clinical studies should be carried out on a large scale for economic production. Author Contributions: Conceptualization, M.M.I.; and M.M.E.-S.; software, B.S.A.; validation, M.M.E.-S.; and M.M.I.; resources, M.M.I.; data curation, B.S.A.; writing—original draft preparation, M.M.I.; writing—review and editing, M.M.E.-S.; visualization, B.S.A.; supervision, M.M.E.-S.; project administration, M.M.E.-S.; funding acquisition, B.S.A.; All authors have read and agreed to the published version of the manuscript. Funding: This research received no external funding. Conflicts of Interest: The authors declare no conflict of interest. References 1. Wan, A.H.; Davies, S.J.; Soler-Vila, A.; Fitzgerald, R.; Johnson, M.P. Macroalgae as a sustainable aquafeed ingredient. Rev. Aquac. 2019, 11, 458–492. [CrossRef] 2. Ismail, M.M.; Gheda, S.F.; Pereira, L. Variation in bioactive compounds in some seaweed from Abo Qir bay, Alexandria, Egypt. Rend Lincei-Sci. Fis. 2016, 27, 269–279. 3. Torres, M.D.; Flórez-Fernández, N.; Domínguez, H. Integral utilization of red seaweed for bioactive production. Mar. Drugs 2019, 17, 314. [CrossRef] 4. Vieira, E.F.; Soares, C.; Machado, S.; Correia, M.; Ramalhosa, M.J.; Oliva-Teles, M.T.; Carvalho, A.P.; Domingues, V.F.; Antunes, F.; Oliveira, T.A.C.; et al. Seaweeds from the Portuguese coast as a source of proteinaceous material, total and free amino acid composition profile. Food Chem. 2018, 269, 264–275. [PubMed] 5. Paiva, L.; Lima, E.; Patarra, R.F.; Neto, A.I.; Baptista, J. Edible Azorean macroalgae as source of rich nutrients with impact on human health. Food Chem. 2014, 164, 128–135. 6. Gómez-Guzmán, M.; Rodríguez-Nogales, A.; Algieri, F.; Gálvez, J. Potential role of seaweed polyphenols in cardiovascular-associated disorders. Mar. Drugs 2018, 16, 250. [CrossRef] 7. Abu-Khudir, R.; Ismail, G.A.; Diab, T. Antimicrobial, antioxidant, and anti-Tumor activities of Sargassum linearifolium and Cystoseira crinita from Egyptian Mediterranean Coast. Nutr. Cancer 2020. [CrossRef] 8. El-Sheekh, M.; El Sabbagh, S.; Abd El Samea, B. Control of some microbial skin diseases by some marine algal extract. J. Agric. Chem. Biotechnol. 2016, 7, 67–74. [CrossRef] 9. Bhuyar, P.; Rahim, M.H.; Sundararaju, S.; Maniam, G.P.; Govindan, N. Antioxidant and antibacterial activity of red seaweed; Kappaphycus alvarezii against pathogenic bacteria. Global J. Environ. Sci. Manag. 2020, 6, 47–58. 10. Ratnawati, R.; Prasetyaningrum, A.; Wardhani, D.H. Kinetics and thermodynamics of ultrasound-assisted depolymerization of ҡ-carrageenan. Bull. Chem. React. Eng. Catal. 2016, 11, 48–58. [CrossRef] 11. Zheng, J.; Chen, Y.; Yao, F.; Chen, W.; Shi, G. Chemical composition and antioxidant/antimicrobial activities in supercritical carbon dioxide fluid extract of Gloiopeltis tenax. Mar. Drugs 2012, 10, 2634–2647. [CrossRef] [PubMed] 12. Smyrniotopoulos, V.; Vagias, C.; Rahman, M.M.; Gibbons, S.; Roussis, V. Ioniols I and II, tetracyclic diterpenes with antibacterial activity, from Sphaerococcus coronopifolius. Chem. Biodivers. 2010, 7, 666–676. [CrossRef] [PubMed] 13. Brito, I.; Cueto, M.; Díaz-Marrero, A.R.; Darias, J.; San Martín, A. Oxachamigrenes, New Halogenated Sesquiterpenes from Laurencia obtusa. J. Nat. Prod. 2002, 65, 946–948. [CrossRef] 14. Blunt, J.W.; Copp, B.R.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2003, 20, 1–48. [CrossRef] [PubMed] 15. Padmakumar, K.; Ayyakkannu, K. Seasonal variation of antibacterial and antifungal activities of the extract of marine algae from southern coasts of India. Bot. Mar. 1997, 40, 507–515. [CrossRef] 16. Saleh, B.; Al-Mariri, A. Antifungal activity of crude seaweed extracts collected from Lattakia Coast, Syria. J. Fish. Aquat. Sci. 2018, 13, 49–55. [CrossRef] 17. Rodrigues, D.; Alves, C.; Horta, A.; Pinteus, S.; Silva, G.; Culioli, G.; Thomas, O.P.; Pedrosa, R. Antitumor and antimicrobial potential of bromoditerpenes isolated from the Red Alga, Sphaerococcus coronopifolius. Mar. Drugs 2015, 13, 713–726. [CrossRef]PDF Image | Therapeutic Uses of Red Macroalgae
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