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Photomedicine and Laser Surgery Volume 32, Number 2, 2014 a Mary Ann Liebert, Inc. Pp. 93–100 DOI: 10.1089/pho.2013.3616 A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase Alexander Wunsch1 and Karsten Matuschka2 Abstract Objective: The purpose of this study was to investigate the safety and efficacy of two novel light sources for large area and full body application, providing polychromatic, non-thermal photobiomodulation (PBM) for improving skin feeling and appearance. Background data: For non-thermal photorejuvenation, laser and LED light sources have been demonstrated to be safe and effective. However, lasers and LEDs may offer some disadvantages because of dot-shaped (punctiform) emission characteristics and their narrow spectral band- widths. Because the action spectra for tissue regeneration and repair consist of more than one wavelength, we investigated if it is favorable to apply a polychromatic spectrum covering a broader spectral region for skin rejuvenation and repair. Materials and methods: A total of 136 volunteers participated in this prospective, randomized, and controlled study. Of these volunteers, 113 subjects randomly assigned into four treatment groups were treated twice a week with either 611–650 or 570–850nm polychromatic light (normalized to *9 J/cm2 in the range of 611–650 nm) and were compared with controls (n = 23). Irradiances and treatment durations varied in all treatment groups. The data collected at baseline and after 30 sessions included blinded evaluations of clinical photography, ultrasonographic collagen density measurements, computerized digital profilometry, and an assessment of patient satisfaction. Results: The treated subjects experienced significantly improved skin complexion and skin feeling, profilometrically assessed skin roughness, and ultrasonographically measured collagen density. The blinded clinical evaluation of photographs confirmed significant improvement in the intervention groups compared with the control. Conclusions: Broadband polychromatic PBM showed no advantage over the red-light-only spectrum. However, both novel light sources that have not been previously used for PBM have demonstrated efficacy and safety for skin rejuvenation and intradermal collagen increase when compared with controls. Introduction Altering cellular function using low level, non- thermal LED light is called photobiomodulation (PBM) or low-level light therapy (LLLT), and is a medical treatment modality of increasing clinical importance.1 Because of the combination of high degree of penetration in skin2 and ab- sorption by respiratory chain components, light in the spectral range from 600 to 1300 nm is useful for promoting wound healing, tissue repair, and skin rejuvenation.3–5 In contrast to traumatic ablative (e.g., laser resurfacing) and non-ablative (e.g., intense pulsed light [IPL]) skin rejuvenation modalities that induce secondary tissue repair by causing controlled 1Medical Light Consulting, Heidelberg, Germany. 2JK-International GmbH, Windhagen, Germany. damage to either the epidermis or the dermis, PBM is atrau- matic, and bypasses the initial destructive step by directly stimulating regenerative processes in the skin. Its action mechanisms encompass increased cellular proliferation, mi- gration, and adhesion.6 Important cell types for skin and tis- sue regeneration are fibroblasts, keratinocytes, and immune cells (mast cells, neutrophils, and macrophages), which can be stimulated using specific wavelengths with significant tissue penetration properties.7 The known severe side effects of traumatic skin rejuvenation procedures, such as inflamma- tion, unpleasant pain perception, and prolonged social down time,8 are unknown in PBM; PBM has been successfully ad- ministered to reduce common symptoms of laser resurfacing 93PDF Image | Trial to Determine the Efficacy of Red Near-Infrared Light Treatment
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