PDF Publication Title:
Text from PDF Page: 007
Biphasic dose response in low level light therapy FIGURE 3. Mitochondrial respiratory chain consisting of contains five complexes of integral mem- brane proteins: NADH dehydrogenase (Complex I), succinate dehydrogenase (Complex II), cytochrome c reductase (Complex III), cytochrome c oxidase (Complex IV), and ATP synthase (ComplexV). or hypoxic cells (Brown 2001). Increased nitric oxide (NO) concentra- tions can sometimes be measured in cell culture or in animals after LLLT due to its photo release from the mitochondria and Cox. It has been pro- posed that LLLT might work by photodissociating NO from Cox, thereby reversing the mitochondrial inhibition of respiration due to excessive NO binding (Lane 2006). Figure 4 illustrates the photodissociation of NO from its binding sites on the heme iron and copper centers where it cometively inhibits oxygen binding and reduces necessary enzymic activ- ity, thus allowing an immediate influx of oxygen and resumption of res- piration and generation of reactive oxygen species. 2.5. NO signaling In addition to NO being photodissociated from Cox as described, it may also be photo-released from other intracellular stores such as nitrosy- lated hemoglobin and nitrosylated myoglobin (Shiva and Gladwin 2009). Light mediated vasodilation was first described in 1968 by R F Furchgott, in his nitric oxide research that lead to his receipt of a Nobel Prize thirty years later in 1998 (Mitka 1998). Later studies conducted by other researchers confirmed and extended Furchgott’s early work and demon- strated the ability of light to influence the localized production or release of NO and stimulate vasodilation through the effect NO on cyclic guaninePDF Image | BIPHASIC DOSE RESPONSE IN LOW LEVEL LIGHT THERAPY
PDF Search Title:
BIPHASIC DOSE RESPONSE IN LOW LEVEL LIGHT THERAPYOriginal File Name Searched:
Biphasic-Dose-Response-in-Low-Level-Light-Therapy-Harvard.pdfDIY PDF Search: Google It | Yahoo | Bing
Cruise Ship Reviews | Luxury Resort | Jet | Yacht | and Travel Tech More Info
Cruising Review Topics and Articles More Info
Software based on Filemaker for the travel industry More Info
The Burgenstock Resort: Reviews on CruisingReview website... More Info
Resort Reviews: World Class resorts... More Info
The Riffelalp Resort: Reviews on CruisingReview website... More Info
CONTACT TEL: 608-238-6001 Email: greg@cruisingreview.com (Standard Web Page)