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Y-Y. Huang and others 608 TABLE 2. Biphasic dose response studies of LLLT in vivo (animal models). Year Tissue 1979 wound closure 2001 Induced heart attacks Laser characteristics Fluence Irradiance Reference Ginsbach 1979 Oron et al. 2001 in rats 2005 Mouse pleurisy induced by Carrageenan 650nm laser; 2.5 mW in 0.08 cm2; 3 J/cm2, 7.5 J/cm2, and 15 J/cm2 Inflammator y cell migration reduction most at 7.5 J/cm2; Less at 3 and 15 J/cm2 Lopes-Martins et al. 2005 Lanzafame et al. 2007 Demidova-Rice et al. 2007 2007 Healing of pressure ulcers in mice 670nm LED; 5 J/cm2 at 0.7, 2, 8 or 40mW/cm2 Healing significant improved only at 8mW/cm2;Less at 0.7, 2, and 40 mW/cm2 820nm was the best wavelength 2007 Full thickness dorsal excisional wound in a single exposure from 635, 670, 720 or 820nm filtered lamp; 1, 2, 10 and 50 J/cm2; 100 mW/cm2 10, 20, 100 and 500 seconds 810-nm laser; 3 and 30 J/cm2; Healing effect best at 2 J/cm2 for 635nm light; worse at 50 J/cm2 for most wavelengths compared to no treatment BALB/c mice 2007 Inflammator y arthritis 30 J/cm2 was better than 3 J/cm2 has effective at 5mW/cm2 Castano et al. 2007 induced by zymosan in rats 5 mW/cm2 and 50 mW/cm2 3 J/cm2 at 50mW/cm2 but not 50mW/cm2 TABLE 3. Biphasic dose response studies of LLLT in clinical studies. Year Patients 1997 Patients with post herpetic Laser characteristics 830nm lasers; 60mW laser and 150mW Fluence Irradiance Reference Hashimoto et al. 1997 neuralgia of the facial type laser; irradiance point at 4mm in diameter 60mW laser when exposure to the same time. He-Ne laser4 J/cm2 810 nm laser; 2.5 to 20mW/cm2 ; Wound healing best at 45 mW/cm2; least at 12.4 mW/cm2 Reductions of infarct size maximum at 5mW/cm2 Lower effects both at 2.5mW/cm2 and 20mW/cm2 Pain reduction greater at 150mW laser; less atPDF Image | BIPHASIC DOSE RESPONSE IN LOW LEVEL LIGHT THERAPY AN UPDATE
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