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Biphasic Dose Response in LLLT – An Update FIG. 3. Three-dimensional model of the Arndt-Schulz curve illustrating how either irradiance or illu- mination time (fluence) can have biphasic dose response effects in LLLT. CURRENT BIPHASIC DOSE RESPONSE STUDIES IN LLLT. In this section we cover the new reports of biphasic dose responses in LLLT that have been published in the last two years since our previous review. In an oral mucositis hamster model Lopes and coworkers (Lopes et al. 2009) delivered 660-nm laser at two different irradiances (55 mW/cm2 for 16 seconds per point or 155 mW/cm2 for 6 seconds per point). Both regimens delivered 0.9 J/cm2 per point. On day 7, 11 and 15 the authors reported reduced severity of clinical mucositis and lower levels of COX-2 staining in the 55 mW/cm2 group and that the 155 mW/cm2 had no sig- nificant differences when compared with controls. This data is summa- rized in Figure 4. Gal et al (Gal et al. 2009) compared the effects of delivering 5 J/cm2 of 670-nm laser at different power densities on wound tensile strength in a rat model. They found (Figure 5) that 670 nm laser achieved a signifi- cant effect using 4mW/cm2 applied for 1,250 seconds (20 mins 50 sec- onds) but that this effect was lost if the same 5J/cm2 fluence was delivered at 15 mW/cm2 for 333 seconds (5 mins 33 seconds). (Skopin and Molitor 2009) studied the effects of different influences of 980 nm laser on a human fibroblast in vitro model of wound healing. 609PDF Image | BIPHASIC DOSE RESPONSE IN LOW LEVEL LIGHT THERAPY AN UPDATE
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