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Pharmacological Interventions Sertraline. The selective serotonin reuptake inhibitor (SSRI) sertraline has been shown to be useful in the treatment and management of symptoms of NES (Miyaoka et al., 2003; O’Reardon, Stunkard, & Allison, 2004). In a study by O’Reardon & Stunkard et al. (2004), sertraline was given to 17 persons meeting criteria for NES in a 12 week open-label, non-blind trial. Results were impressive and resulted in a reduction of nocturnal awakenings, nocturnal ingestions, evening hyperphagia, and improved ratings on the Clinical Global Impression of Improvement Scale in all 17 participants, including a complete reduction in symptoms in 5 of the participants (O’Reardon & Stunkard et al., 2004). O'Reardon, et al., (2006) aimed to test the effectiveness of sertraline in a randomized, double-blind, placebo-controlled trial. They recruited 34 participants with NES and randomly assigned 17 participants to receive sertraline and 17 to receive the placebo. Patients who received sertraline showed significant decreases in nocturnal ingestions, evening hyperphagia, depressive symptoms, nocturnal awakenings, and had a mean weight loss of 2.9 kilograms after 8-weeks of treatment. In a follow up study, Stunkard and colleagues (2006) followed 50 patients that were prescribed sertraline by their own physician. These persons contacted the researchers through their website, by phone, or via email requesting help for their NES and were offered consultation for their participation. Participants were initially screened using the NEQ and the NESHI to verify the diagnosis of NES. For the next 8 weeks the participants were asked to complete assessments every 2 weeks and were assessed by phone at week 8 to determine progress (Stunkard et al., 2006). The authors found significant reductions in symptoms of NES and a mean weight loss of 3.0 kilograms after 8-weeks of treatment. 19PDF Image | BRIGHT LIGHT THERAPY FOR late NIGHT EATING SYNDRome
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