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Lexapro. Vander Wal and colleagues (2012) recently evaluated the short term effects of escitalopram (Lexapro; selective serotonin reuptake inhbitor) for the treatment of NES (Vander Wal, Gang, Griffing, & Gadde, 2012) in a double-blind randomized controlled clinical trial. Forty participants meeting criteria for NES were randomly assigned to receive either 20 mg of escialopram or a placebo for 12-weeks. Primary outcome was a mean change in total scores on the Night Eating Questionnaire (NEQ). At 12-weeks, there were non-significant reductions in total score on the NEQ in both the intervention and control group. Of note, both groups documented participants that no longer met criteria for NES at the conclusion of the 12-week study: 16 participants in the intervention group versus 12 patients in the control group. Essentially, Lexapro was not more effective than a placebo in the treatment of NES (Vander Wal et al., 2012). Topiramate. Topiramate (anticonvulsant) may also be of use in the treatment of night eating syndrome. In a case study, nocturnal ingestions were reduced at 100% with the use of topiramate in one patient and three other patients had a marked to moderate decrease in symptoms (Winkelman, 2003). In another case report involving a 40 year old woman with comorbid NES and PTSD, a dose of 100 mg of topiramate given at night resulted in reduction of PTSD symptoms, NES, and resulted in 70 pound weight loss (Tucker, Masters, & Nawar, 2004). Further research is needed to demonstrate the efficacy of topiramate for the treatment of NES. Chronobiological Interventions: Bright Light Therapy (BLT) Chronobiological treatments, such as BLT, have been considered as a treatment option for NES. To date, two case studies have been reported that address this relationship. The first is a case study of a 51-year old obese woman meeting criteria for depression and night eating 20PDF Image | BRIGHT LIGHT THERAPY FOR late NIGHT EATING SYNDRome
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