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Healthcare 2020, 8, 10 5 of 14 2.9. Data Availability Data available on request from the authors. 3. Results Between 1 September 2017 and 1 May 2018, 47 cancer survivors completed the prescreening questionnaire, and 15 were eligible for the personalized trial of light therapy. Nine cancer survivors Healthcare 2020, 8, x FOR PEER REVIEW 5 of 14 were assigned to this series of personalized trials comparing BWL versus DRL (Figure 1). Six patients were assigned to personalized trials comparing two sham treatments (dim white versus dim red light), were assigned to personalized trials comparing two sham treatments (dim white versus dim red which are not further discussed here. The mean age of these nine patients was 54 years, 78% were light), which are not further discussed here. The mean age of these nine patients was 54 years, 78% women, 78% were white, and 33% were Hispanic (Table 1). The most common type of cancer was breast were women, 78% were white, and 33% were Hispanic (Table 1). The most common type of cancer cancer (56%). None had metastatic disease. Two-thirds of patients had at least moderate depressive was breast cancer (56%). None had metastatic disease. Two-thirds of patients had at least moderate symptoms (i.e., PHQ-8 score ≥ 10) and the mean PHQ-8 score was 10. Most patients (seven out of depressive symptoms (i.e., PHQ-8 score ≥ 10) and the mean PHQ-8 score was 10. Most patients (seven nine) were already engaging in some form of depression treatment, and most patients (six out of nine) out of nine) were already engaging in some form of depression treatment, and most patients (six out preferred shared decision-making with their doctor. of nine) preferred shared decision-making with their doctor. Figure 1. Patient ffllow diagram. Abbreviations: WR//RW, balanced treatment sequence beginning with bright whiittelligighhttththeerarappyy(W(W, R, WRW/W/WR,Rb,ablanlacnedcetdretartematemntensetqsueeqnucenbcegbinegninngiwngithwditihmdriemd lriegdhtli(gRh)t. (R). Overall, eight out of nine patients completed the 12-week personalized trial, the ninth patient droppOevdeoraultl,oefitghhettroiualt ionftnhientehiprdatwieenetsk cdoume ptolepterdcetihved12l-awckeeokf bpeenresfiotnsaolifzeidthteriatyl,ptehoefnlignhtht tphaertiaepnyt. Fdoror pthpedeigohuttpoaftitehnetstrwiahloincotmhepltehteirdthweepekrodtouceolt,odepperecsesiivedsylamckptofmbaesnsefsistsmoefntesitwheretyrepceorodfeldigohnt 7th2e.0r%apoyf. pFosrstihbeleedigahyts p(ia.eti.e, n60ts.5wShDo8c.o8mdapylestoeduttohfeapprotsoscibole, d8e4pdraeyssivtoetasly)mptom assessments were recorded on 72.0% of possible days (i.e., 60.5 SD 8.8 days out of a possible 84 days total) 3.1. Outcomes and Estimation Table 1. Baseline patient characteristics (N = 9). The results of the individual personalized trials are presented in Table 2 and in Figure A2. Overall, BWL was associated with significantly fewer patient-reported depressive symptoms in two patients, Characteristic Mean (SD) or n (Percentage) no significant difference in five patients, and worse depressive symptoms in one patient (Figure 2). A with BWL versus DRL. Hispanic Race: White Black Other Cancer type: Breast Thyroid 3 (33%) Age in years, mean (SD) 54.2 (17.7) similar pattern was observed with respect to fatigue symptoms, with just one patient reporting lower Female 7 (78%) fatigue, six patients reporting no difference in fatigue severity, and one patient reporting higher fatigue 7 (78%) 1 (11%) 1 (11%) 5 (56%) 2 (22%)PDF Image | Bright White Light Therapy for Depression in Cancer Survivors
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