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15 Despite the similarities in the effects of LED phototherapy to LLLT, there have been no publications on the effects of LED phototherapy on OTM in humans to date. Given the safety of LEDs as compared to lasers (Casalechi et al., 2009, Eells et al., 2004) and the fundamental similarities at the biological level, this study investigates the role of LED phototherapy on OTM with the intention of establishing a foundation for IR- LED phototherapy mediated increases in OTM rates. This study will also offer opportunities to understand the cellular and molecular mechanisms that underlie OTM and possibly tissue repair/regeneration and in more general terms, connective tissue metabolism. 1.8 HYPOTHESIS The overall hypothesis of this study is that IR-LED phototherapy can alter the rate of OTM over the first 3 months of active extraction space closure. To address this hypothesis, patients undergoing bilaterally symmetrical extraction space closure will be exposed to IR-LED phototherapy in a split mouth manner.PDF Image | Effect of LED Phototherapy on the Rate of Orthodontic Tooth Movement
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