PDF Publication Title:
Text from PDF Page: 002
FIG. 1. Growth phase specificity of 3T3 fibroblasts; combined wavelengths; 4 J/cm2 versus 8 J/cm2; 50 mW/cm2. wound healing of ischemic, hypoxic, and infected wounds.1 Lasers provide low-energy stimulation of tissues that results in increased cellular activity during wound healing.2,3 These activities include collagen production and angiogene- sis.4 HBO therapy, which is currently standard therapy in the treatment of diabetic ulcers, graft failures, radiation necrosis, and other ischemic wounds, has also been shown to beneficially affect these processes. However, there are a variety of instances in which a patient who may benefit from HBO is unable or un- willing to be treated in a high-pressure environment. These sit- uations include lack of access to a facility equipped with HBO, claustrophobia, and certain current or chronic medical condi- tions that would make HBO therapy contraindicated. In these instances, light therapy provides an alternative for the patient. Wound healing has three phases: first, a substrate is laid down, second, cells proliferate, and third, there is remodeling of tissue. The data published so far suggests that laser biostimula- tion produces its primary effect during the cell proliferation phase of the wound healing process. It has been demonstrated that mitochondria are receptive to monochromatic near-infrared light and that laser light likely increases respiratory metabolism of certain cells.2,3,5 Processes such as fibroblast proliferation, attachment and synthesis of collagen and procollagen, growth factor production (including keratinocyte growth factor [KGF], transforming growth factor [TGF], and platelet-derived growth factor [PDGF]), macrophage stimulation, lymphocyte stimula- tion,6 and greater rate of extracellular matrix production have been reported with laser light treatment.7–14 Animal studies on the enhanced wound healing effect of laser light of low-power density have been performed in toads, mice, rats, guinea pigs, and swine.15,16 Human studies with laser light have demon- strated greater amounts of epithelialization for wound closure and stimulation of skin graft healing.1,9 An excellent review of recent human experience with near-infrared light therapy for wound healing was published by Conlan et al. in 1996.1 Lasers, however, have some inherent characteristics that make their use in a clinical setting problematic, including limi- tations in wavelength capabilities and beam width. The com- bined wavelengths of the light for optimal wound healing can- not be efficiently produced, the size of wounds that may be treated is limited (due to laser production of a beam of light—a fact inconsistent with treating large areas), heat production from the laser light itself can actually damage tissue, and the pinpoint beam of laser light can damage the eye. NASA devel- Whelan et al. 306 FIG. 2. Growth phase specificity of osteoblasts; individual wavelengths; 8 J/cm2; 50 mW/cm2.PDF Image | Effect of NASA Light-Emitting Diode Irradiation on Wound Healing
PDF Search Title:
Effect of NASA Light-Emitting Diode Irradiation on Wound HealingOriginal File Name Searched:
Effect-of-NASA-light-emitting-diode-irradiation-on-wound-healing.pdfDIY PDF Search: Google It | Yahoo | Bing
Cruise Ship Reviews | Luxury Resort | Jet | Yacht | and Travel Tech More Info
Cruising Review Topics and Articles More Info
Software based on Filemaker for the travel industry More Info
The Burgenstock Resort: Reviews on CruisingReview website... More Info
Resort Reviews: World Class resorts... More Info
The Riffelalp Resort: Reviews on CruisingReview website... More Info
| CONTACT TEL: 608-238-6001 Email: greg@cruisingreview.com | RSS | AMP |