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CHAPTER 3 Figure 3.3 Dorsal column somatosensory functional deficits from T10 hemicontusion spinal cord injury is reversed by red light treatment. (a) Schematic of experimental paradigm for evaluating somatosensory (dorsal column pathway) functional integrity illustrating left and right dorsal column pathways (grey), T10 hemicontusion injury on right side, stimulation of sural nerves, and location of recording electrode on midline of gracile nucleus. The same electrode position on the midline acquires somatosensory responses independently evoked from both left and right sural nerves, enabling direct comparable quantification of sensory pathways on both sides. Examples of responses (between 5-15 ms post- stimulus; 500-3350 Hz bandpass) evoked from left and right sides shown for respective groups (colour-coded as per legend in c and Figure 3.2). Arrowheads indicate latency of response onset. (b) Quantification (integral of rectified signals) of gracile nucleus response magnitudes (right expressed as a percent of left). (c) Difference in latencies of evoked responses between left and right sides. Note magnitudes and latencies from intact animals are equal on both sides (control group). * p < 0.05; ** p < 0.01, Student’s t-test, Tukey’s post-hoc in c). 3.4.5 Red light improves locomotor recovery Could red light treatment cause motor deficits and thereby result in reduced sensitivity scores? To rule out the possibility that the red light impeded the animals’ ability to perform escaping locomotor behaviours, daily locomotor recovery was examined blind to the experimental group (Figure 3.4). It was found that rather than impeding locomotion, the SCI+670 group (n = 11) demonstrated improved locomotor recovery as early as 2 days post-injury on the ipsilateral side, and 3 days post-injury on the contralateral side compared to the sham-treated group (n = 10). Although a group effect of red light improvement was evident on the ipsilateral side (p = 0.026, linear mixed effects model with repeated measures), this failed to reach significance on the contralateral side (p = 0.055). There was a highly significant effect of time for both sides (p < 2e-16). Locomotor improvements observed in the SCI+670 group indicate that reduced 67PDF Image | Effects of Red Light Treatment on Spinal Cord Injury
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