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2 LITTERATURE REVIEW 2.3.2.2 Melanopsin The Melanopsin system controls the biological clock, as the main Zeitge- ber for SCN, through short wavelength light entering the eye. In the human eye, the Melanopsin level is adjusted in correlation to the light intake, send- ing a message to the SCN, that controls which hormones are released to the body. (Xue et al., 2011) Melanopsin also is found in the iris of mice and primates, rats and chor- dates. (Chellappa et al., no date; Drouyer et al., no date; Xue et al., 2011; Halper, 2016) 2.3.2.3 Serotonin (Happy) Seotonin works as a neurotransmitter in the brain, if the Serotonin levels are low it can point to bad immune function and lead to depression. Sea- sonal Serotonin dysregulation shows correlations between SAD and BN, but not AN. (Kennedy, 1994; Tasegian et al., 2016) Serotonin is popularly known as the happy hormone because of its relaxing effect and sense of wellbeing. Antidepressants like Prozac works by speeding up this process. 2.3.2.4 Orexin (hypocretin) Orexin is regulated by SCN like Melatonin and is a protein regulated by orexin-neurons, keeping track of the human sleep/wake balance, food intake and energy metabolism (Figure 6). A study comparing Orexin A (OXA) levels in untreated girls with AN to healthy girls, shows significantly higher OXA levels in AN but no correlation with Leptin. (Bronsky et al., 2011) (Figure 6) Master thesis · MSc Lighting Design · Pernille Bech-Larsen · Fall 2017 21 Figure 6, SCN Orexin regulation of Glucose (Tsuneki, H. et al, 2016)PDF Image | Healing with light
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