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Penetration Depth [mm ± standard error] n = 10 0.92 ± 0.08 1.38 ± 0.13 2.17 ± 0.16 2.52 ± 0.19 To investigate which wavelength within the optical tissue window will penetrate the deepest and deliver the highest dose, the values for the tissue absorption coefficient as well as the penetration depth were extracted from [24] and [47] and extrapolated by use of polynomial trend lines as shown in Figure 3. Figure 3: Using the literature reports on the transmittance of near infrared light through the scalp and skull, as well as the penetration depth inside the brain, mathematical trends are established in order to use meaningful values when calculating the supplied dose of wavelengths that are not covered by literature [9]. While Figure 3 suggest that a wavelength between 700 nm and 830 nm is likely to have the most effective and also the deepest delivery of light energy to areas inside the brain, an article by Wu et al claims that illumination with 730 nm and 980 nm appears to be ineffective when used as a modality for traumatic brain injury in mice and they suggest to use a mix of 665 nm and 810 nm instead [48]. Enengl, Dungel #neverforget – PBM vs AD: A Systematic Review Page 14 of 25PDF Image | Photobiomodulation Against Alzheimer’s Disease
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