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ACCEPTED MANUSCRIPT Figure 3. Müller cell-derived inflammation was mitigated by exposure to 670nm light following photo-oxidative damage (PD). A: Timeline of experimental paradigm. B-E: Müller cells exposed to 670nm light had significantly reduced Nox1 (B), Nox4 (C), Ccl2 (D) and Il-6 (E) expression compared to untreated Müller cells (P<0.05). F-G: CCL2 and IL-6 in co- culture supernatant was significantly decreased by 670nm light post-PD (P<0.05). DIV; days in vitro. N=6 was used for all experimental comparisons and was performed in biological triplicate. The data is presented as the mean ± SEM. * denotes a significant change (P<0.05). Colour should be used 31 ACCEPTED MANUSCRIPTPDF Image | Photobiomodulation with 670 nm light ameliorates retinal
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