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Military Special Operations are characterized by lightly equipped, highly mobile troops entering situations requiring optimal physical conditioning at all times. Wounds are an obvious physical risk during combat operations. Any simple and lightweight equipment that promotes wound healing and musculoskeletal rehabilitation and conditioning has potential merit. An LED array with 3 wavelengths combined in a single unit (670, 720, and 880 nm) was delivered to Naval Special Warfare Group-2 (SEALS) in Norfolk, VA. Treatment was 4 J/cm2, 10 mW/cm2. Results and Discussion Near infrared (IR) light has documented benefits promoting wound healing in human and animal studies. Our preliminary results have also demonstrated two to five-fold in- creases in growth-phase-specific DNA synthesis in normal fibroblasts, muscle cells, os- teoblasts, and mucosal epithelial cells in tissue cultures treated with near-IR light. Our animal models treated with near-IR have included wound healing in diabetic mice and ischemic bipedical skin flap in rats. Near-IR induced a thirty percent increase in the rate of wound closure in these animal models. Dose- and time-dependent increases in vas- cular endothelial growth factor (VEGF) and fibroblast growth factor (FGF-2) occurred in animals treated with near-IR. Human studies have included the use of near-IR to pre- vent ulcerative mucositis resulting from high doses of chemotherapy and radiation. Widely published reports, including those from our laboratory, described accelerated recovery from musculoskeletal injuries, hypoxic-ischemic wounds, burns, lacerations, radiation necrosis, and diabetic ulcers with the use of near-IR. Lasers have some in- herent characteristics, which make their use in a clinical setting problematic, including limitations in wavelength capabilities and beam width. The combined wavelengths of light optimal for wound healing cannot be efficiently produced, and the size of wounds which may be treated by lasers is limited. Light-emitting diodes (LEDs) developed for NASA crewed spaceflight experiments offer an effective alternative to lasers. These diodes can be made to produce multiple wavelengths, and can be arranged in large, flat arrays allowing treatment of large wounds. Conclusion We are now investigating new collaborations with the Defense Advanced Research Projects Agency (DARPA) for military applications of LED wound healing technology in military medicine. Several uniquely military situations and indications could be addressed, optimizing near-IR parameters for wound healing via LEDs during extended missions under conditions separated from medical personnel. These include burns, chemical agents, radiation, biological agents and highly infected flesh-eating wounds (with and without extended burns) typical for the hygienic conditions occurring in battle fields, also infectious diseases and external wounds occurring in environments with no solar irra- diation, low oxygen and high carbon dioxide (submarines). The dramatic results with use of near-IR LED light to prevent digestive mucosal lesions (mucositis) and pain in cancer patients, after high-dose chemotherapy and radiation, suggest the potential for 34PDF Image | THE USE OF NASA LED NEAR-INFRARED TECHNOLOGY FOR BIOSTIMULATION
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