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International Journal of Photoenergy 5 Control GCL INL ONL (a) GCL INL ONL (f) GCL INL ONL (k) 9 J/cm2 18 J/cm2 36 J/cm2 90 J/cm2 TUNEL BBZ (b) (c) (d) (e) (g) (h) (i) (j) (l) (m) (n) (o) Figure 2: Representative images of the effects of 670 nm light treatment on photoreceptor cell death induced by exposure to different intensities of white light. Images were all taken from the same area in the superior portion of the retina. ((a)–(e)) 750-lux light damage. TUNEL counts were highest in light damage controls with a reduction in TUNEL+ cells seen in retinas that underwent 9 and 18 J/cm2 670 nm light treatment. There were no visible changes between the control and 36 J/cm2 treatments but an increase was seen in the 90 J/cm2 treatments. ((f)–(j)) 1000-lux light damage. Similar to the 750-lux paradigm, TUNEL counts were highest in light damage controls with a reduction in TUNEL+ cells seen in retinas that underwent 9 and 18 J/cm2 670 nm light treatment. No visible differences were seen between the control and 36 J/cm2 treatments. Treatments with a dose of 90 J/cm2 670 nm light appeared to increase the amount of TUNEL+ cells in the ONL. ((k)–(o)) 1500-lux light damage. All retinas stained positive with a high amount of TUNEL cells with only 90 J/cm2 treatments appearing to reduce TUNEL+ cell counts (scale bars indicate 50 𝜇m; BBZ is a bisbenzimide stain). damaged controls (Figure 3(a)). Treatment with 90 J/cm2 resulted in no significant difference in ONL ratios compared with the light damaged controls. 3.1.3. 670 nm Light Effects in High Intensity Light Damage. Treatment doses of 9, 18, and 36J/cm2 had no effect on levels of cell death in “high” intensity (1500 lux) light damaged retinas (Figures 1(d), 2(k)–2(n)). However, in this group pretreatment with 90 J/cm2 significantly reduced the TUNEL+ cell count (Figure 2(o)). Similarly, there was no significant difference in mean ONL thickness across the retinas of animals treated with 9, 18, or 36 J/cm2 red light, compared to light damaged controls (Figure 3(a)). However, a 90 J/cm2 pretreatment dose resulted 1500 lux 1000 lux 750 luxPDF Image | 670 nm Light Therapy to Protect vs Photoreceptor Cell Death
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